{"product_id":"2940013207523","title":"T Cell Activation","description":"2009 marked the 25th anniversary of the first Annual Review of Immunology article to describe features of the T cell antigen receptor (TCR). In celebration of this anniversary, we begin with a brief introduction outlining the chronology of the earliest studies that established the basic paradigm for how the engaged TCR transduces its signals. This review continues with a description of the current state of our understanding of TCR signaling, as well as a summary of recent findings examining other key aspects of T cell activation, including cross talk between the TCR and integrins, the role of costimulatory molecules, and how signals may negatively regulate T cell function.","brand":"Annual Reviews","offers":[{"title":"Default Title","offer_id":47069953327344,"sku":"2940013207523","price":9.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0737\/7593\/9824\/files\/2940013207523_p0.jpg?v=1763577926","url":"https:\/\/shop-qa.barnesandnoble.com\/products\/2940013207523","provider":"Barnes \u0026 Noble (DEV)","version":"1.0","type":"link"}