{"product_id":"2940013247208","title":"T Follicular Helper (TFH) Cells in Normal and Dysregulated Immune Responses","description":"T cell help for antibody production is a fundamental aspect of immune responses. Only recently has a better understanding of the cellular and molecular mechanisms for T cell help emerged. A subset of T cells, termed T follicular helper cells (TFH cells), provides a helper function to B cells and represents one of the most numerous and important subsets of effector T cells in lymphoid tissues. TFH cells are distinguishable from Th1 and Th2 cells by several criteria, including chemokine receptor expression (CXCR5), location\/migration (B cell follicles), and function (B cell help). Central to the function of CD4+ T cells is IL-21, a “helper” cytokine produced by TFH cells that potently stimulates the differentiation of B cells into Ab-forming cells through IL-21R. Consequently, dysregulation of TFH cell function, and over- or under-expression of TFH cell–associated molecules such as ICOS or IL-21, most likely contributes to the pathogenesis of certain autoimmune diseases or immunodeficiencies.","brand":"Annual Reviews","offers":[{"title":"Default Title","offer_id":47069844078832,"sku":"2940013247208","price":9.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0737\/7593\/9824\/files\/2940013247208_p0.jpg?v=1763578896","url":"https:\/\/shop-qa.barnesandnoble.com\/products\/2940013247208","provider":"Barnes \u0026 Noble (DEV)","version":"1.0","type":"link"}