{"product_id":"2940013294820","title":"Human Marginal Zone B Cells","description":"Human marginal zone (MZ) B cells are, in a sense, a new entity. Although they share many properties with their mouse counterpart, they also display striking differences, such as the capacity to recirculate and the presence of somatic mutations in their B cell receptor. These differences are the reason they are often not considered a separate, rodent-like B cell lineage, but rather are considered IgM memory B cells. We review here our present knowledge concerning this subset and the arguments in favor of the proposition that humans have evolved for their MZ B cell compartment a separate B cell population that develops and diversifies its Ig receptor during ontogeny outside T-dependent or T-independent immune responses.","brand":"Annual Reviews","offers":[{"title":"Default Title","offer_id":47169168015600,"sku":"2940013294820","price":9.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0737\/7593\/9824\/files\/2940013294820_p0.jpg?v=1763579349","url":"https:\/\/shop-qa.barnesandnoble.com\/products\/2940013294820","provider":"Barnes \u0026 Noble (DEV)","version":"1.0","type":"link"}