{"product_id":"2940013305441","title":"Properdin: Emerging Roles of a Pattern-Recognition Molecule","description":"Complement is an innate immune system that is a first line of defense against pathogens and facilitates elimination of apoptotic and injured cells. During complement activation, the complement convertases are assembled on target surfaces and initiate their proteolytic activities, a process that marks targets for phagocytosis and\/or lysis. The complement alternative activation pathway has been implicated in a number of autoimmune conditions including arthritis and age-related macular degeneration. Properdin, a plasma component that is also released by activated neutrophils, is critical in the stabilization of alternative pathway convertases. Recently, it has been shown that properdin is also a pattern-recognition molecule that binds to certain microbial surfaces, apoptotic cells, and necrotic cells. Once bound to a surface, properdin can direct convertase formation and target uptake. New studies are now focusing on a role for properdin in inflammatory and autoimmune diseases. This review examines the new properdin findings and their implications.","brand":"Annual Reviews","offers":[{"title":"Default Title","offer_id":47184655089904,"sku":"2940013305441","price":9.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0737\/7593\/9824\/files\/2940013305441_p0.jpg?v=1763590778","url":"https:\/\/shop-qa.barnesandnoble.com\/products\/2940013305441","provider":"Barnes \u0026 Noble (DEV)","version":"1.0","type":"link"}