{"product_id":"2940013316744","title":"Functions of Notch Signaling in the Immune System: Consensus and Controversies","description":"Mammalian genomes encode up to four Notch receptors (Notch1–4) and five Notch ligands of the DSL (Delta\/Serrate\/Lag-2) family, and Notch signaling controls a wide spectrum of developmental processes. Intrathymic Notch1 signaling is essential for several distinct aspects of early T cell development. Notch signaling has also been implicated as a key regulator of peripheral T cell activation and effector cell differentiation, but its functions in these processes remain poorly understood. Notch signaling is dispensable for B cell development in the bone marrow, but it is required to generate the innate-like marginal zone B cell subset in the spleen and may also regulate plasma cell functions. Modification of Notch receptors by fringe glycosyltransferases influences many Notch-dependent aspects of hematopoiesis by altering Notch responsiveness to Delta-like versus Jagged DSL ligands. Here we review recent advances in general aspects of Notch signaling, as well as studies probing Notch functions in these immunological processes.","brand":"Annual Reviews","offers":[{"title":"Default Title","offer_id":47082683990256,"sku":"2940013316744","price":9.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0737\/7593\/9824\/files\/2940013316744_p0.jpg?v=1763579382","url":"https:\/\/shop-qa.barnesandnoble.com\/products\/2940013316744","provider":"Barnes \u0026 Noble (DEV)","version":"1.0","type":"link"}