{"product_id":"2940045082044","title":"A Simple Guide to Genetic Diseases","description":"\u003cp\u003eA genetic disease is a disease caused by a abnormal form of a gene called a variation or a change of a gene called a mutation.\u003c\/p\u003e\u003cp\u003eGenetic disorders can be caused\u003cbr\u003e1. by a mutation in one gene (monogenetic disorder)\u003c\/p\u003e\u003cp\u003eMonogenetic disorders are relatively rare and are caused by a mutation in a single gene.\u003c\/p\u003e\u003cp\u003eThe mutation may be present on one or both chromosomes (one chromosome inherited from each parent).\u003cbr\u003eExamples of monogenic disorders are: sickle cell disease, cystic fibrosis, polycystic kidney disease, and Tay-Sachs disease.\u003c\/p\u003e\u003cp\u003eA mutated gene can be inherited through a family.\u003c\/p\u003e\u003cp\u003eEach generation of children can inherit the gene that causes the disease.\u003c\/p\u003e\u003cp\u003eMonogenic disorders can be:\u003cbr\u003ea. Dominant diseases are caused by the presence of the disease gene on just one of the two inherited parental chromosomes.\u003cbr\u003eIn dominant diseases, the chance of a child inheriting the disease is 50 percent.\u003c\/p\u003e\u003cp\u003eIn a family situation, for example, if the parents have four children, it may be possible that two of those children inherit the disease gene.\u003cbr\u003eExamples of dominant diseases are Huntington's chorea and Marfan syndrome.\u003c\/p\u003e\u003cp\u003eb. Recessive diseases require the presence of the disease gene on both of the inherited parental chromosomes.\u003c\/p\u003e\u003cp\u003eIn this case, the chance of a child inheriting a recessive disease is 25 percent.\u003cbr\u003eIn the family example, if the parents have four children, it may be more likely that only one child will develop the disease. Examples of recessive diseases include cystic fibrosis and Tay-Sachs disease.\u003c\/p\u003e\u003cp\u003e2. by mutations in multiple genes (multifactorial inheritance disorder)\u003c\/p\u003e\u003cp\u003eMost genetic disorders, however, are \"multifactorial inheritance disorders,\" meaning they are caused by a combination of inherited mutations in multiple genes, often acting together with environmental factors.\u003c\/p\u003e\u003cp\u003eBehaviors are also multifactorial, involving multiple genes that are affected by a variety of other factors.\u003c\/p\u003e\u003cp\u003eResearchers are learning more about the genetic contribution to behavioral disorders such as alcoholism, obesity, mental illness and Alzheimer's disease.\u003c\/p\u003e\u003cp\u003e3. by a combination of gene mutations and environmental factors\u003c\/p\u003e\u003cp\u003eMultifactorial inheritance disorders are caused by a combination of small inherited variations in genes, often acting together with environmental factors.\u003c\/p\u003e\u003cp\u003eHeart disease, diabetes, and most cancers are examples of such disorders.\u003c\/p\u003e\u003cp\u003e4. by damage to chromosomes (changes in the number or structure of entire chromosomes, the structures that carry genes)\u003c\/p\u003e\u003cp\u003eChromosome disorders are caused by an excess or deficiency of the genes that are located on chromosomes, or by structural changes within chromosomes.\u003c\/p\u003e\u003cp\u003eIn Down syndrome there is an extra copy of chromosome 21. (called trisomy 21), although no individual gene on the chromosome is abnormal.\u003c\/p\u003e\u003cp\u003eA specific form of blood cancer (chronic myeloid leukemia, CML) may be caused by a chromosomal translocation, in which portions of two chromosomes (chromosomes 9 and 22) are exchanged.\u003c\/p\u003e\u003cp\u003eNearly all diseases have a genetic component.\u003c\/p\u003e\u003cp\u003eSome diseases are caused by mutations that are inherited from the parents like sickle cell disease.\u003c\/p\u003e\u003cp\u003eOther diseases are caused by acquired mutations in a gene or group of genes that occur during a person's life.\u003c\/p\u003e\u003cp\u003eSuch mutations are not inherited from a parent, but occur either randomly or due to some environmental exposure (such as cigarette smoke). These include many cancers, as well as some forms of neurofibromatosis.\u003c\/p\u003e\u003cp\u003eRarely, one of these monogenic diseases can occur spontaneously in a child when his\/her parents do not have the disease gene, or there is no history of the disease in the family.\u003c\/p\u003e\u003cp\u003eThis can result from a new mutation occurring in the egg or sperm that gave rise to that child.\u003c\/p\u003e\u003cp\u003eTABLE OF CONTENT\u003c\/p\u003e\u003cp\u003eGenetic Diseases\u003c\/p\u003e\u003cp\u003eChapter 1 Down’s Syndrome\u003c\/p\u003e\u003cp\u003eChapter 2 G6PD Deficiency\u003c\/p\u003e\u003cp\u003eChapter 3 Hemophilia\u003c\/p\u003e\u003cp\u003eChapter 4 Klinefetter’s Syndrome\u003c\/p\u003e\u003cp\u003eChapter 5 Marfan’s Syndrome\u003c\/p\u003e\u003cp\u003eChapter 6 Thalassemia\u003c\/p\u003e\u003cp\u003eChapter 7 Turner’s Syndrome\u003c\/p\u003e","brand":"Kenneth Kee","offers":[{"title":"Default Title","offer_id":47173044535536,"sku":"2940045082044","price":2.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0737\/7593\/9824\/files\/2940045082044_p0.jpg?v=1769889808","url":"https:\/\/shop-qa.barnesandnoble.com\/products\/2940045082044","provider":"Barnes \u0026 Noble (DEV)","version":"1.0","type":"link"}