{"product_id":"2940045350013","title":"A Simple Guide to Cushing's Syndrome and Related Conditions","description":"\u003cp\u003eCushing’s Syndrome\u003c\/p\u003e\u003cp\u003eWhat is Cushing’s syndrome?\u003c\/p\u003e\u003cp\u003eCushing’s syndrome is a disease which is caused by the exposure of the body to excessive quantities of glucocorticoids steroids.\u003c\/p\u003e\u003cp\u003ePeople of all ages are affected but more are seen in females between 30 to 50 years of age.\u003c\/p\u003e\u003cp\u003eWhat are the causes of Cushing Syndrome?\u003c\/p\u003e\u003cp\u003eThe causes are believed to be:\u003cbr\u003e1. Cushing Disease -excessive production of adrenocorticotrophin hormone (ACTH) by the pituitary gland causes bilateral adrenal (gland above kidney) hyperplasia (overgrowth of gland tissue).\u003c\/p\u003e\u003cp\u003eThe enlarged adrenal gland will produce excessive corticosteroids.\u003c\/p\u003e\u003cp\u003eA pituitary basophile or chromphobe adenoma may be present.\u003c\/p\u003e\u003cp\u003e2. Adrenal tumors which may be benign or malignant can produce excessive corticosteroids\u003c\/p\u003e\u003cp\u003e3. Ectopic ACTH syndrome\u003c\/p\u003e\u003cp\u003eProduction of ACTH by a tumor such as cancer of the lung leads to adrenal hyperplasia\u003c\/p\u003e\u003cp\u003e4. Iatrogenic -patients receiving excessive doses of corticosteroids may present as Cushing syndrome\u003c\/p\u003e\u003cp\u003eWhat are the symptoms of Cushing Syndrome?\u003c\/p\u003e\u003cp\u003eSymptoms of Cushing Syndrome:\u003cbr\u003e1. Obesity predominally truncal often with pad of fat between shoulders (buffalo hump)\u003c\/p\u003e\u003cp\u003e2. Round flat plethoric (red) face (moon face)\u003c\/p\u003e\u003cp\u003e3. Skin is thin and bruises easily\u003c\/p\u003e\u003cp\u003e4. Purple striae on abdomen, thighs, and shoulders.\u003c\/p\u003e\u003cp\u003e5. Proximal myopathy leads to difficulty in getting out of chairs and walking upstairs\u003c\/p\u003e\u003cp\u003e6. Excessive adrenal androgen secretions lead to hirsutism, amenorrhea and acne\u003c\/p\u003e\u003cp\u003e7. Osteoporosis can lead to back pain\u003c\/p\u003e\u003cp\u003e8. Hypertension and glycosuria (glucose in urine) are common\u003c\/p\u003e\u003cp\u003e9. Depression and other psychiatric disturbance common\u003c\/p\u003e\u003cp\u003e10. In children there may stunting of growth\u003c\/p\u003e\u003cp\u003e11. Women with Cushing syndrome often have:\u003cbr\u003ea. Excess hair growth on the face, neck, chest, abdomen, and thighs\u003cbr\u003eb. Menstrual cycles that are irregular or stops\u003c\/p\u003e\u003cp\u003e12. Men may have:\u003cbr\u003ea. Impotence\u003cbr\u003eb. Reduced or no desire for sex\u003c\/p\u003e\u003cp\u003eHow is the Diagnosis of Cushing Syndrome made?\u003c\/p\u003e\u003cp\u003eDiagnosis of Cushing Syndrome:\u003cbr\u003e1. The typical moon face and buffalo hump can suggest the diagnosis of Cushing Syndrome\u003c\/p\u003e\u003cp\u003e2. 24 hour urine cortisol tests\u003c\/p\u003e\u003cp\u003e3. Overnight dexamethasone suppression test\u003c\/p\u003e\u003cp\u003e4. Plasma ACTH level\u003c\/p\u003e\u003cp\u003e5. Chest X-ray to exclude lung cancer\u003c\/p\u003e\u003cp\u003e6. X-ray of pituitary fossa to exclude pituitary tumors\u003c\/p\u003e\u003cp\u003e7. Ultrasound of adrenal glands for enlargement\u003c\/p\u003e\u003cp\u003eWhat are the complications of Cushing Syndrome?\u003c\/p\u003e\u003cp\u003eComplications of Cushing Syndrome:\u003cbr\u003e1. Hypertension\u003c\/p\u003e\u003cp\u003e2. Fractures from osteoporosis\u003c\/p\u003e\u003cp\u003e3. Stunted growth in children\u003c\/p\u003e\u003cp\u003eWhat is the treatment of Cushing’s syndrome?\u003c\/p\u003e\u003cp\u003eTreatment of Cushing’s syndrome:\u003cbr\u003eCushing's syndrome is treated by surgery, radiation treatments or drugs.\u003c\/p\u003e\u003cp\u003eOften if there is a tumor on just one adrenal gland, the other gland often becomes smaller and stops normal hormone production\u003c\/p\u003e\u003cp\u003eHormone supplements are always given before any surgical treatment and should be taken for months after surgery until the second adrenal gland recovers its normal function.\u003c\/p\u003e\u003cp\u003e1. Anti-adrenal drug such as aminogluthemide\u003cbr\u003eThis drug blocks the production of steroids formed from cholesterol.\u003cbr\u003eIt is clinically used in the treatment of Cushing's syndrome and metastatic breast cancer.\u003c\/p\u003e\u003cp\u003e2. Bilateral adrenalectomy\u003c\/p\u003e\u003cp\u003e3. Surgery to remove pituitary tumor\u003c\/p\u003e\u003cp\u003e4. Surgery to remove primary neoplasm in lungs or pancreas\u003c\/p\u003e\u003cp\u003e5. In cases of adrenal gland cancer, chemotherapy and radiation can also be used to treat the cancer.\u003cbr\u003eSurgery is a last resort.\u003c\/p\u003e\u003cp\u003e6. In iatrogenic Cushing’s syndrome, reduction of ingestion of corticosteroids to the lowest dosage possible has to done to control the illness.\u003c\/p\u003e\u003cp\u003eTABLE OF CONTENT\u003c\/p\u003e\u003cp\u003eChapter 1\u003c\/p\u003e\u003cp\u003eCushing’s Syndrome\u003c\/p\u003e\u003cp\u003eChapter 2\u003c\/p\u003e\u003cp\u003eAdrenal Tumors\u003c\/p\u003e\u003cp\u003eChapter 3\u003c\/p\u003e\u003cp\u003eCorticosteroids\u003c\/p\u003e\u003cp\u003eChapter 4\u003c\/p\u003e\u003cp\u003eEpilogue\u003c\/p\u003e","brand":"Kenneth Kee","offers":[{"title":"Default Title","offer_id":47110340673776,"sku":"2940045350013","price":2.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0737\/7593\/9824\/files\/2940045350013_p0.jpg?v=1763974252","url":"https:\/\/shop-qa.barnesandnoble.com\/products\/2940045350013","provider":"Barnes \u0026 Noble (DEV)","version":"1.0","type":"link"}