{"product_id":"2940046472837","title":"Life And Death Of A Macrophage Cell (Macrophage)","description":"\u003cp\u003eMy name is Macrophage the macrophage.\u003c\/p\u003e\u003cp\u003eI was named Macrophage by my friends who feel there is no other name for me.\u003c\/p\u003e\u003cp\u003eSome of them even wanted to call me Super Phage or Big Eater.\u003c\/p\u003e\u003cp\u003eWe are white blood cells within tissues produced by the division of monocytes.\u003c\/p\u003e\u003cp\u003eOur cells are large about 21 micrometers in diameter, still one-fifth of an ovum.\u003c\/p\u003e\u003cp\u003eThe human ovum measures approximately 100 micrometers in diameter and is the biggest cell.\u003c\/p\u003e\u003cp\u003eWe often have an elongated irregular shape that reflects our amoeboid wandering nature.\u003c\/p\u003e\u003cp\u003eThere may be many of us in one region but we are not contiguous.\u003c\/p\u003e\u003cp\u003eWe display our inclusions only as a result of substantial phagocytic activity.\u003c\/p\u003e\u003cp\u003eThe Monocytes and we are phagocytes acting in both:\u003cbr\u003e1. Non-specific defenses (innate immunity)\u003c\/p\u003e\u003cp\u003e2. Specific defense mechanisms (adaptive immunity) of humans.\u003c\/p\u003e\u003cp\u003eOur role is to:\u003cbr\u003e1. Phagocytose (engulf and then digest) cellular debris and pathogens either as stationary or as mobile cells\u003c\/p\u003e\u003cp\u003e2. Stimulate lymphocytes and other immune cells to respond to the pathogen.\u003c\/p\u003e\u003cp\u003eWe move by action of amoeboid movement.\u003c\/p\u003e\u003cp\u003eWhen a white blood cell enters the damaged tissue through the endothelium of a blood vessel (a process known as the leukocyte extravasations), it undergoes a series of changes to become a one of us macrophages\u003c\/p\u003e\u003cp\u003eMonocytes are attracted to a damaged site by chemical substances through chemotaxis triggered by a range of stimuli including damaged cells, pathogens and cytokines released by us already at the site.\u003c\/p\u003e\u003cp\u003eAt some sites such as the testis, we have been shown to populate the organ through proliferation.\u003c\/p\u003e\u003cp\u003eUnlike short-lived neutrophils, we survive longer in the body up to a maximum of several months.\u003c\/p\u003e\u003cp\u003eAn important role of us the macrophages is the removal of necrotic cellular debris in the lungs.\u003c\/p\u003e\u003cp\u003eRemoving dead cell material is important in chronic inflammation as the early stages of inflammation are dominated by neutrophil granulocytes which are ingested by us if they come of age.\u003c\/p\u003e\u003cp\u003eThe removal of necrotic tissue is handled by our fixed macrophage cells which will stay at strategic locations such as the lungs, liver, neural tissue, bone, spleen and connective tissue ingesting foreign materials such as pathogens recruiting more of us if needed.\u003c\/p\u003e\u003cp\u003eWhen I ingest a pathogen, the pathogen becomes trapped in a phagosome which then fuses with a lysosome.\u003c\/p\u003e\u003cp\u003eWithin the phagolysosome, enzymes and toxic peroxides digest the pathogen.\u003c\/p\u003e\u003cp\u003eHowever some bacteria such as Mycobacterium tuberculosis have become resistant to these methods of digestion.\u003c\/p\u003e\u003cp\u003eWe can digest more than 100 bacteria before we finally die due to our own digestive compounds, usually after a period of several months.\u003c\/p\u003e\u003cp\u003eA Little Information on the Macrophage\u003c\/p\u003e\u003cp\u003eMacrophages (big eater) are cells produced by the changes of monocytes in tissues.\u003c\/p\u003e\u003cp\u003eHuman macrophages are about 21 micrometers (0.00083in) in diameter.\u003c\/p\u003e\u003cp\u003eParts of a Macrophage:\u003c\/p\u003e\u003cp\u003e1. Pathogens\u003cbr\u003e2. Phagosome\u003cbr\u003e3. Lysosomes\u003cbr\u003e4. Waste material\u003cbr\u003e5. Cytoplasm\u003cbr\u003e6. Cell membrane\u003c\/p\u003e\u003cp\u003eLife cycle of a macrophage:\u003c\/p\u003e\u003cp\u003eWhen a monocyte enters the outside damaged tissue through the endothelium of a blood vessel, a process known as the leukocyte extravasation, it undergoes a series of changes to become a macrophage.\u003c\/p\u003e\u003cp\u003eMonocytes are attracted to a damaged site by chemical substances through chemotaxis triggered by a range of stimuli including damaged cells, pathogens and cytokines released by macrophages already at the site.\u003c\/p\u003e\u003cp\u003eAt some sites such as the testis macrophages have been shown to populate the organ through proliferation.\u003c\/p\u003e\u003cp\u003eUnlike short-lived neutrophils, macrophages survive longer in the body up to a maximum of several months.\u003c\/p\u003e\u003cp\u003eTABLE OF CONTENT\u003c\/p\u003e\u003cp\u003eChapter 1 Story of Macrophage\u003c\/p\u003e\u003cp\u003eChapter 2 Life Cycle of Macrophage\u003c\/p\u003e\u003cp\u003eChapter 3 Formation of a Macrophage\u003c\/p\u003e\u003cp\u003eChapter 4 Death of a Macrophage\u003c\/p\u003e\u003cp\u003eChapter 5 Tuberculosis\u003c\/p\u003e","brand":"Kenneth Kee","offers":[{"title":"Default Title","offer_id":47110776914160,"sku":"2940046472837","price":2.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0737\/7593\/9824\/files\/2940046472837_p0.jpg?v=1764001817","url":"https:\/\/shop-qa.barnesandnoble.com\/products\/2940046472837","provider":"Barnes \u0026 Noble (DEV)","version":"1.0","type":"link"}