{"product_id":"2940148626404","title":"Investigation of the Effect of Sodium Selenate on Acetylcholinesterase Activity under Extremely Low Frequency Electromagnetic Field","description":"Acetylcholinestrase (AChE EC 3.1.1.7) is one of the most important enzymes in nervous\u003cbr\u003esystem, which plays a role in Alzheimer’s disease. Selenium is a vital micronutrient and\u003cbr\u003emany investigations have been performed about the physiological, biochemical and\u003cbr\u003ebehavioral effects of this element, such as postponing the Alzheimer's symptoms in the\u003cbr\u003eelderly and delaying the initiation signs of skin aging. Recent studies have shown that this\u003cbr\u003eelement protects various enzymes against the toxicity caused by heavy metals such as; Pb, Al,\u003cbr\u003eCu and Cd. AChE activity is altered under the influence of extremely low frequency\u003cbr\u003eelectromagnetic field (ELF-EMF). In this study, the effects of ELF-EMF, with 0.3 mT field\u003cbr\u003eintensity and 50, 100, 217 Hz frequencies, were investigated on the AChE, in the presence of\u003cbr\u003edifferent concentrations of sodium selenate, using UV-Visible, fluorescence and circular\u003cbr\u003edichroism spectroscopic techniques. The results demonstrated that the enzyme activity\u003cbr\u003edeclined by increasing the frequency and the amount of sodium selenate. Also, significant\u003cbr\u003estructural changes occurred in the secondary and tertiary structures of AChE. Our results \u003cbr\u003eshowed that with increasing the concentration of sodium selenate transition from α-helix to\u003cbr\u003eβ-structure was appeared in the presence of ELF-EMF. In conclusion, according to changes\u003cbr\u003eobserved in the secondary and tertiary structure of enzyme, it is proposed that these fields are\u003cbr\u003eable to affect the structure and dynamics of the active site gorge of AChE.","brand":"ReadCycle","offers":[{"title":"Default Title","offer_id":47075387605232,"sku":"2940148626404","price":2.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0737\/7593\/9824\/files\/2940148626404_p0.jpg?v=1763706518","url":"https:\/\/shop-qa.barnesandnoble.com\/products\/2940148626404","provider":"Barnes \u0026 Noble (DEV)","version":"1.0","type":"link"}