{"product_id":"2940148814214","title":"The Effect of Rosemary (Rosmarinus officinalis. L) Plant Extracts on the Immune Response and Lipid Profile in Mice","description":"The hypolipidemic activity of leaves of rosemary (Rosmarinus officinalis), a herbal plant was\u003cbr\u003estudied. Three groups of BALB\/c mice were treated as following: the first group was fed with\u003cbr\u003enormal diet (sugar \u0026amp; water), the second group was fed with high cholesterol (HC) (2% by\u003cbr\u003eweight) and coconut oil (25% by weight), for 36 days, and the third group was fed with HC\u003cbr\u003ediet and given 100 mg\/kg rosemary extract (10% w\/v) during the last 15 days of treatment\u003cbr\u003eperiod. There was a significant decrease (P \u0026lt; 0.001) in plasma total cholesterol (TC)(-\u003cbr\u003e68.57%), low density lipoprotein (LDL) (- 56.34%), and triglycerides (TG) (- 182.61%). A\u003cbr\u003esignificant increase in high density lipoprotein (HDL) (38.53%) was obtained in\u003cbr\u003erosemary-fed mice compared to HC mice. In another experiment, the immunomodulatory\u003cbr\u003eactivity of aqueous extract of R. officinalis was evaluated in BALB\/c mice. Mice were treated\u003cbr\u003ewith three doses of extract (10, 50, 100 mg\/kg body weight) for 8 weeks. Humoral immunity\u003cbr\u003eagainst membrane proteins of sheep erythrocytes measured by ELISA showed that IgM\u003cbr\u003e(Immunoglobulin M) response significantly increased by 26.95%, 36.5%, 70.78%\u003cbr\u003erespectively, in mice fed with 10, 50, and 100 mg\/kg of rosemary as compared to the control\u003cbr\u003egroup (P \u0026lt; 0.05). IgG (Immunoglobulin G) response increased significantly at all antibody\u003cbr\u003etiters, in mice fed with rosemary at doses of 10, 50, and 100 mg\/kg. Meanwhile, there was no\u003cbr\u003esignificant different in IgM and IgG responses between 50 and 100 mg\/kg (P \u0026gt; 0.05). On the\u003cbr\u003eother hand, concanavalin A-stimulated proliferation of spleen cells from mice fed with 100\u003cbr\u003emg rosemary extract was significantly higher by 57% than that of cells from the\u003cbr\u003ecorresponding control animals.","brand":"ReadCycle","offers":[{"title":"Default Title","offer_id":47108882792688,"sku":"2940148814214","price":2.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0737\/7593\/9824\/files\/2940148814214_p0.jpg?v=1763709063","url":"https:\/\/shop-qa.barnesandnoble.com\/products\/2940148814214","provider":"Barnes \u0026 Noble (DEV)","version":"1.0","type":"link"}