{"product_id":"2940153790268","title":"Pemphigus, A Simple Guide To The Condition, Diagnosis, Treatment And Related Conditions","description":"\u003cp\u003ePemphigus is a medical autoimmune disorder that produces blistering and sores (erosions) of the skin and mucous membranes.\u003cbr\u003ePemphigus is derived from the Greek 'pemphix' (bubble).\u003cbr\u003ePemphigus includes most bullous eruptions but improved diagnostic tests have permitted a re-categorization of bullous diseases.\u003cbr\u003eThe bullae are superficial and confined to the epidermal layer.\u003cbr\u003eThis is distinguished from bullous pemphigoid where bullae are sub-epidermal.\u003cbr\u003e3 major types of the disorder have been described, each with characteristic medical and immunological features:\u003cbr\u003e1. Pemphigus vulgaris (PV) is the most frequent subset or variant and is responsible for 70% of cases of pemphigus.\u003cbr\u003e2. Pemphigus foliaceus (PF) is characterized by lesions which happen only in the skin and linked with antibodies to desmoglein 1 (DSG1).\u003cbr\u003e3. Pemphigus herpetiformis, paraneoplastic pemphigus, IgA pemphigus, and IgG pemphigus are rarer forms\u003cbr\u003eThe exact cause is unknown.\u003cbr\u003eSometimes pemphigus is caused by certain medications\u003cbr\u003e1. About 50% of people with this condition first form painful sores and blisters in the mouth, later developing skin blisters.\u003cbr\u003e2. Skin sores may come and go.\u003cbr\u003eThe skin sores may be described as:\u003cbr\u003ea. Draining\u003cbr\u003eb. Oozing\u003cbr\u003ec. Crusting\u003cbr\u003ed. Peeling or easily detached\u003cbr\u003eThey may be located:\u003cbr\u003e1. In the mouth\u003cbr\u003e2. On the scalp, trunk, or other skin areas\u003cbr\u003eThe oral cavity is most frequently involved (almost all cases).\u003cbr\u003eBuccal, gingival, and palatine lesions occur.\u003cbr\u003eA skin biopsy is normally done to confirm the diagnosis.\u003cbr\u003eSkin biopsy should be from the edge of a blister and preferably examined fresh rather than in media of transport of the biopsy specimen resulting in a risk of false-negative results.\u003cbr\u003eGeneral measures are advising patients with painful oral lesions to have soft foods and the use of soft toothbrush.\u003cbr\u003eTopical anesthetics or analgesics may give some symptomatic relief.\u003cbr\u003eMost of the patients are treated with systemic corticosteroid treatment which normally results in full remission.\u003cbr\u003eIntravenous immunoglobulin may be used to induce remission in resistant cases, normally with a cytotoxic treatment such as azathioprine.\u003cbr\u003ePlasma exchange and extracorporeal photopheresis have also been tried successfully as adjuvant treatment in severe and resistant cases.\u003c\/p\u003e\u003cp\u003eTABLE OF CONTENT\u003cbr\u003eIntroduction\u003cbr\u003eChapter 1 Pemphigus\u003cbr\u003eChapter 2 Causes\u003cbr\u003eChapter 3 Symptoms\u003cbr\u003eChapter 4 Diagnosis\u003cbr\u003eChapter 5 Treatment\u003cbr\u003eChapter 6 Prognosis\u003cbr\u003eChapter 7 Impetigo\u003cbr\u003eChapter 8 Furuncle\u003cbr\u003eEpilogue\u003c\/p\u003e","brand":"Kenneth Kee","offers":[{"title":"Default Title","offer_id":47070427545840,"sku":"2940153790268","price":2.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0737\/7593\/9824\/files\/2940153790268_p0.jpg?v=1764057411","url":"https:\/\/shop-qa.barnesandnoble.com\/products\/2940153790268","provider":"Barnes \u0026 Noble (DEV)","version":"1.0","type":"link"}