{"product_id":"2940153812991","title":"A Simple Guide to The Spleen And Its Function (What You Need To Recycle RBCs)","description":"\u003cp\u003eThe spleen is an organ present in all humans.\u003cbr\u003eSimilar in structure to a large lymph node, it acts primarily as a blood filter.\u003cbr\u003eThus life is possible after the spleen is removed.\u003cbr\u003eThe spleen plays important roles in regard to red blood cells and the immune system.\u003cbr\u003eIt removes old red blood cells and holds a reserve of blood in case of hemorrhagic shock and also recycles iron.\u003cbr\u003eAs a part of the mononuclear phagocyte system, it metabolizes hemoglobin removed from senescent erythrocytes.\u003cbr\u003eThe globin portion of hemoglobin is degraded to its constitutive amino acids and the heme portion is metabolized to bilirubin, which is removed in the liver.\u003cbr\u003eThe spleen synthesizes antibodies in its white pulp and removes antibody-coated bacteria and antibody-coated blood cells by way of blood and lymph node circulation\u003cbr\u003eThese monocytes, upon moving to injured tissue turn into dendritic cells and macrophages while promoting tissue healing.\u003cbr\u003eThe spleen is a center of activity of the reticuloendothelial system and can be considered analogous to a large lymph node as its absence causes a predisposition to certain infections.\u003cbr\u003eIn humans, the spleen is brownish in color and is located in the left upper quadrant of the abdomen.\u003cbr\u003eThe spleen is located in the upper left part of the abdomen under the ribcage.\u003cbr\u003eIt works as part of the lymphatic system to protect the body, clearing worn-out red blood cells and other foreign bodies from the bloodstream to help fight off infection\u003cbr\u003eThe spleen also helps the body fight infection.\u003cbr\u003eThe spleen contains lymphocytes and another kind of white blood cell called macrophages which engulf and destroy bacteria, dead tissue, and foreign matter and remove them from the blood passing through the spleen.\u003cbr\u003eThe spleen helps control the amount of blood and blood cells that circulate through the body and helps destroy damaged cells.\u003cbr\u003eThe spleen is part of the lymphatic system.\u003cbr\u003eThe Red Pulp has the function of mechanical filtration of red blood cells\u003cbr\u003eThe White pulp produces an active immune response through humoral and cell-mediated pathways\u003cbr\u003eThe spleen is composed of nodules, called Malpighian corpuscles.\u003cbr\u003eThese are composed of:\u003cbr\u003e1. Lymphoid follicles rich in B-lymphocytes\u003cbr\u003e2. Periarteriolar lymphoid sheaths (PALS) rich in T-lymphocytes\u003cbr\u003eOther functions of the spleen are less prominent, especially in the healthy adult:\u003cbr\u003e1. Production of opsonins, properdin, and tuftsin.\u003cbr\u003e2. Creation of red blood cells.\u003cbr\u003eWhile the bone marrow is the primary site of hematopoiesis in the adult, the spleen has important hematopoietic functions up until the fifth month of gestation.\u003cbr\u003eAfter birth, erythropoietic functions cease, except in some hematologic disorders.\u003cbr\u003eAs a major lymphoid organ and a central player in the reticuloendothelial system, the spleen retains the ability to produce lymphocytes and, as such, remains a hematopoietic organ.\u003cbr\u003e3. Storage of red blood cells, lymphocytes and other formed elements.\u003cbr\u003eThe red blood cells can be released when needed\u003cbr\u003eIn humans, up to a cup (236.5 ml) of red blood cells can be held in the spleen and released in cases of hypovolemia.\u003cbr\u003eIt can store platelets in case of an emergency.\u003cbr\u003eUp to a quarter of lymphocytes can be stored in the spleen at any one time.\u003cbr\u003eThe spleen is enlarged for various reasons such as cancer specifically blood-based leukemias.\u003cbr\u003eBut in some cases, more serious diseases such as cancer can cause the spleen to expand.\u003cbr\u003eTraumas such as a motor vehicle accident can cause rupture of the spleen.\u003cbr\u003eThis is a situation that requires immediate medical attention.\u003c\/p\u003e\u003cp\u003eTABLE OF CONTENT\u003cbr\u003eIntroduction\u003cbr\u003eChapter 1 The Spleen\u003cbr\u003eChapter 2 Spleen Function\u003cbr\u003eChapter 3 The Immune system of the Spleen\u003cbr\u003eChapter 4 Protection of the Spleen\u003cbr\u003eChapter 5 The Spleen and Diseases\u003cbr\u003eEpilogue\u003c\/p\u003e","brand":"Kenneth Kee","offers":[{"title":"Default Title","offer_id":47074626044144,"sku":"2940153812991","price":2.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0737\/7593\/9824\/files\/2940153812991_p0.jpg?v=1764061285","url":"https:\/\/shop-qa.barnesandnoble.com\/products\/2940153812991","provider":"Barnes \u0026 Noble (DEV)","version":"1.0","type":"link"}