{"product_id":"2940154054918","title":"Acromegaly, A Simple Guide To The Condition, Diagnosis, Treatment And Related Conditions","description":"\u003cp\u003eAcromegaly is a rare disease which is caused when the pituitary gland produces too much growth hormone.\u003cbr\u003eNormally a benign (non cancerous) tumor of the pituitary gland results in the gland producing too much growth hormone.\u003cbr\u003eToo much growth hormone in children produces gigantism rather than acromegaly.\u003cbr\u003eSymptoms of acromegaly are:\u003cbr\u003e1. Reduced muscle strength (weakness)\u003cbr\u003e2. Reduced peripheral vision\u003cbr\u003e3. Easy fatigue\u003cbr\u003e4. Increased height\u003cbr\u003e5. Large bones of the face\u003cbr\u003e6. Large feet (change in shoe size), large hands (change in ring or glove size)\u003cbr\u003e7. Large glands in the skin (sebaceous glands)\u003cbr\u003e8. Large jaw (prognathism) and tongue (macroglossia)\u003cbr\u003eThere are other symptoms that may occur with this condition:\u003cbr\u003e1. Colon polyps\u003cbr\u003e2. Increased hair growth in females (hirsutism)\u003cbr\u003e3. Type 2 diabetes\u003cbr\u003e4. Enlarged thyroid\u003cbr\u003eTo confirm diagnosis of acromegaly the following tests may be done:\u003cbr\u003e1. Growth hormone\u003cbr\u003e2. Blood glucose\u003cbr\u003e3. High insulin-like growth factor 1 (IGF-1) level\u003cbr\u003e4. Spine x-ray\u003cbr\u003e5. MRI of the brain, including the pituitary gland\u003cbr\u003eTreatment\u003cbr\u003e1. Surgery for removal of the pituitary tumor that is causing this condition often treats the release of abnormal growth hormone.\u003cbr\u003eSometimes the tumor is too big to remove totally.\u003cbr\u003e2. People who are not responsive to surgery may have radiation of the pituitary gland.\u003cbr\u003e3. Tests of pegvisomant (Somavert), a GH-receptor antagonist, showed effective suppression of GH and IGF-I levels in patients with acromegaly due to pituitary tumors or ectopic GHRH hypersecretion.\u003cbr\u003eNormalization of IGF-I levels occurs in as many as 90% of patients treated daily with this drug for 3 months.\u003cbr\u003e4. Bromocriptine (Parlodel, Cycloset)\u003cbr\u003eThis is the dopamine-receptor agonist that is most often used to treat GH and prolactin excess.\u003cbr\u003eIt is safe when administered to a child for extended period.\u003c\/p\u003e\u003cp\u003eIn acromegaly, a severe disease that is often diagnosed late, morbidity and mortality rates are high, particularly as a result of associated cardiovascular, cerebrovascular, and respiratory disorders and malignancies.\u003cbr\u003eBecause IGF-I is a general growth factor, somatic hypertrophy in acromegaly occurs across all organ systems.\u003cbr\u003eAssociated complications include the following:\u003cbr\u003e1. Acromegalic heart\u003cbr\u003e2. Increased muscle and soft tissue mass\u003cbr\u003e3. Increased kidney size\u003cbr\u003e4. Articular overgrowth of synovial tissue and hypertrophic arthropathy\u003cbr\u003e5. Joint symptoms, back pain, and kyphosis\u003c\/p\u003e\u003cp\u003eTABLE OF CONTENT\u003cbr\u003eIntroduction\u003cbr\u003eChapter 1 Acromegaly\u003cbr\u003eChapter 2 Causes\u003cbr\u003eChapter 3 Symptoms\u003cbr\u003eChapter 4 Diagnosis\u003cbr\u003eChapter 5 Treatment\u003cbr\u003eChapter 6 Prognosis\u003cbr\u003eChapter 7 Dwarfism or Growth Hormone Deficiency\u003cbr\u003eEpilogue\u003c\/p\u003e","brand":"Kenneth Kee","offers":[{"title":"Default Title","offer_id":47076239048944,"sku":"2940154054918","price":2.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0737\/7593\/9824\/files\/2940154054918_p0.jpg?v=1764063833","url":"https:\/\/shop-qa.barnesandnoble.com\/products\/2940154054918","provider":"Barnes \u0026 Noble (DEV)","version":"1.0","type":"link"}