{"product_id":"2940154133095","title":"Marfan Syndrome, A Simple Guide To The Condition, Treatment And Related Conditions","description":"\u003cp\u003eMarfan's Syndrome is an inherited disorder of the connective tissue involving the collagen and glyccosamino-glycans tissue.\u003cbr\u003eIt is characterized by generally weak connective tissue which includes muscles, ligaments and bones.\u003cbr\u003eIt is an inherited disease caused by an autosomal dominant gene.\u003cbr\u003eInheritance is passed to 50 per cent of offspring if one parent is affected and 100 per cent of offspring if both parents are affected.\u003cbr\u003eMarfan’s Syndrome can also be from mutation of the genes.\u003cbr\u003ePeople with Marfan Syndrome are usually exceptionally tall with long fingers and rather flat feet.\u003cbr\u003eThey may have a spinal curve (scoliosis) and be shortsighted\u003cbr\u003eThe two heart problems that are most serious are enlargement of the main body artery and leaky heart valves.\u003cbr\u003eWhen the main body artery stretches (aortic aneurysm) it becomes weaker and blood can leak through the wall (dissection or rupture).\u003cbr\u003eAnother heart problem that can occur is leaking of the heart valves.\u003cbr\u003e1. Long slender extremities with arm span exceeding height and long tapered fingers\u003cbr\u003e2. Skeletal deformities include:\u003cbr\u003ea. Kyphoscoliosis\u003cbr\u003eb. Pectus excavatum\u003cbr\u003ec. Long narrow face\u003cbr\u003ed. High arched palate\u003cbr\u003ee. Pronathism\u003cbr\u003e3. Lax ligaments resulting in:\u003cbr\u003ea. Hyperflexiblity of joints\u003cbr\u003eb. Easily strained ligaments and joints\u003cbr\u003ec. Flat feet\u003cbr\u003e4. Eye problems:\u003cbr\u003ea. Dislocation of lens due to lax ligaments\u003cbr\u003eb. Myopia\u003cbr\u003e5. Heart problems:\u003cbr\u003ea. Dilatation of aorta\u003cbr\u003eb. Dilatation of pulmonary artery\u003cbr\u003eDiagnosis of Marfan's Syndrome is often based on:\u003cbr\u003e1. Medical examination of appearance\u003cbr\u003e2. Measurement of metacarpal index from X-rays\u003cbr\u003eRatio of length to midpoint width is greater than 8.5\u003cbr\u003e3. Urinary hydroxyproline is excessive indicating increased collagen turnover\u003cbr\u003e4. Genetic analysis\u003cbr\u003eTreatment of Marfan's Syndrome includes:\u003cbr\u003e1. Genetic counseling\u003cbr\u003e2. Prevention of joint strains especially spinal joints\u003cbr\u003e3. Beta blockers can reduce aortic blood flow and prevent dilatation of aorta\u003cbr\u003eThere may be a shorter life span because of heart and skeletal problems\u003cbr\u003eTABLE OF CONTENT\u003cbr\u003eIntroduction\u003cbr\u003eChapter 1 Marfan Syndrome\u003cbr\u003eChapter 2 More about Marfan Syndrome\u003cbr\u003eChapter 3 Treatment of Marfan Syndrome\u003cbr\u003eChapter 4 Down Syndrome\u003cbr\u003eChapter 5 Klinefelter Syndrome\u003cbr\u003eChapter 6 Turner Syndrome\u003cbr\u003eChapter 7 Huntington’s Chorea\u003cbr\u003eEpilogue\u003c\/p\u003e\u003cp\u003eMarfan's Syndrome is an inherited disease\u003cbr\u003eIt causes the connective tissue an elasticity defect.\u003cbr\u003eIt is usually inherited from autosomal dominant conditions\u003cbr\u003eMarfan Syndrome can also be the result of the gene mutations\u003c\/p\u003e\u003cp\u003eIt is characterized by generally weak connective tissue with great flexibility\u003cbr\u003eMarfan Syndrome is usually exceptionally tall with long extremities\u003cbr\u003eMarfan Syndrome also may have pectus abnormalities\u003cbr\u003eMarfan Syndrome has a spinal curve called scoliosis\u003c\/p\u003e\u003cp\u003eMarfan Syndrome also has eye problems such as eye dislocation\u003cbr\u003eSome have heart problems such as abnormal valve and aortic dissection.\u003cbr\u003eThere is no cure in Marfan Syndrome, only prevention with genetic counseling.\u003cbr\u003eOther treatment is dental care, physical exercise and preventive medicines.\u003cbr\u003e-An original poem by Kenneth Kee\u003c\/p\u003e","brand":"Kenneth Kee","offers":[{"title":"Default Title","offer_id":47070684020976,"sku":"2940154133095","price":2.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0737\/7593\/9824\/files\/2940154133095_p0.jpg?v=1764065123","url":"https:\/\/shop-qa.barnesandnoble.com\/products\/2940154133095","provider":"Barnes \u0026 Noble (DEV)","version":"1.0","type":"link"}