{"product_id":"2940154135815","title":"Lynch Syndrome, A Simple Guide To The Condition, Diagnosis, Treatment And Related Conditions","description":"\u003cp\u003eLynch syndrome is an inherited medical disorder that confers a person a higher risk of cancers of the digestive tract, gynecologic tract, and other organs.\u003cbr\u003eIn Singapore Lynch syndrome has an estimated incidence of 1 in 300 in women and 1 in 500 in the general population.\u003cbr\u003ePeople who have Lynch syndrome have a considerably higher danger of forming:\u003cbr\u003e1. Colorectal cancer (CRC),\u003cbr\u003e2. Endometrial (uterine) cancer,\u003cbr\u003e3. Gastric (stomach) cancer,\u003cbr\u003e4. Ovarian cancer,\u003cbr\u003e5. Small bowel (small intestinal) cancer,\u003cbr\u003e6. Pancreatic cancer,\u003cbr\u003e7. Urinary tract cancer (bladder or ureter cancer),\u003cbr\u003e8. Kidney cancer,\u003cbr\u003e9. Bile duct cancer,\u003cbr\u003e10. Certain skin tumors (sebaceous tumors of the skin or sebaceous adenomas), and\u003cbr\u003e11. Brain tumors.\u003cbr\u003ePeople with Lynch syndrome may also be at slightly higher risk of:\u003cbr\u003e1. Breast cancer and\u003cbr\u003e2. Prostate cancer.\u003cbr\u003eThe old term for Lynch syndrome was “hereditary non-polyposis colorectal cancer” (HNPCC).\u003cbr\u003eThere is no likelihood toward polyp formation and hence the name HNPCC.\u003cbr\u003eIt is the most frequent genetic syndrome linked with a higher vulnerability to Colon cancer.\u003cbr\u003ePatients with Lynch syndrome have a 60%-80% risk for Colorectal Cancer (CRC), as well as a higher risk for cancers, most conspicuously endometrial cancer\u003cbr\u003eEndometrial cancer is the second most frequent malignancy in Lynch syndrome with a lifetime danger between 40% and 60%, often happening before Colorectal Cancer (CRC) in females.\u003cbr\u003eThe average age for colorectal cancer to be diagnosed in a person with Lynch syndrome is 45 in contrast with the average age of 72 for a new diagnosis of colorectal cancer in the general population.\u003cbr\u003eIn Lynch syndrome, colorectal cancer is rather more likely to form on the right side of the colon.\u003cbr\u003eCause:\u003cbr\u003eLynch syndrome is a genetic disorder, indicating that the cancer risk can be passed from generation to generation in a family.\u003cbr\u003eSeveral genes have been identified that are linked to Lynch syndrome.\u003cbr\u003eThey are MLH1, MSH2, MSH6, PMS2, and EPCAM.\u003cbr\u003eA mutation (modification) in any of these genes causes the person to have a higher lifetime danger of forming colorectal cancer and other related cancers.\u003cbr\u003eWomen also have a higher risk of forming endometrial and ovarian cancers.\u003cbr\u003eMaking the diagnosis of Lynch syndrome is normally a 3-stage process, such as:\u003cbr\u003e1. Review of the family cancer history,\u003cbr\u003e2. Tumor testing, and\u003cbr\u003e3. Genetic testing\u003cbr\u003eLynch syndrome, autosomal dominant inheritance disorder, can also be established through a blood test.\u003cbr\u003eThe test can detect if someone has a mutation in one of the genes linked with Lynch syndrome.\u003cbr\u003ePresently testing is provided for the MLH1, MSH2, MSH6, and EPCAM genes.\u003cbr\u003eFor patients who have a family history that indicates Lynch syndrome, screening tests can be done on tumor (cancer) tissue to help detect if Lynch syndrome is possible.\u003cbr\u003eThe two screening tests indicated are micro-satellite instability testing (MSI) and immuno-histo-chemistry testing (IHC).\u003cbr\u003eThe results of these tests can show whether more specific genetic testing should be done.\u003cbr\u003eTreatment:\u003cbr\u003eRemoval of the entire colon is the only way to completely avoid the development of colon cancer or to treat a present colon cancer.\u003cbr\u003e1. Subtotal colectomy with ileorectal anastomosis\u003cbr\u003e2. Total colectomy with ileoanal pull-through (pouch procedure)\u003cbr\u003e3. Total colectomy with ileostomy\u003cbr\u003eSubtotal colectomy with ileo-rectal anastomosis and post-surgical rectal surveillance are advised when colorectal cancer forms in patients with Lynch Syndrome.\u003cbr\u003eThis surgery may be regarded for prevention in selected mismatch repair (MMR) gene mutation carriers.\u003cbr\u003ePrognosis\u003cbr\u003eThe 5-year survival rate in patients with Lynch Syndrome is evaluated to be about 60%, compared with 40-50% for sporadic cases (normal colorectal cases).\u003c\/p\u003e\u003cp\u003eTABLE OF CONTENT\u003cbr\u003eIntroduction\u003cbr\u003eChapter 1 Lynch Syndrome\u003cbr\u003eChapter 2 Causes\u003cbr\u003eChapter 3 Symptoms\u003cbr\u003eChapter 4 Diagnosis\u003cbr\u003eChapter 5 Treatment\u003cbr\u003eChapter 6 Prognosis\u003cbr\u003eChapter 7 Colon Cancer\u003cbr\u003eChapter 8 Cancer of Uterus\u003cbr\u003eEpilogue\u003c\/p\u003e","brand":"Kenneth Kee","offers":[{"title":"Default Title","offer_id":47103550783728,"sku":"2940154135815","price":2.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0737\/7593\/9824\/files\/2940154135815_p0.jpg?v=1764065174","url":"https:\/\/shop-qa.barnesandnoble.com\/products\/2940154135815","provider":"Barnes \u0026 Noble (DEV)","version":"1.0","type":"link"}