{"product_id":"2940154429259","title":"Fanconi Anemia, A Simple Guide To The Condition, Diagnosis, Treatment And Related Conditions","description":"\u003cp\u003eFanconi anemia is an inherited disorder that mainly affects the bone marrow.\u003cbr\u003eIt leads to decreased production of all types of blood cells.\u003cbr\u003eFanconi anemia (FA) is a genetic disorder that eventually leads to bone marrow failure.\u003cbr\u003eThe bone marrow is responsible for making 3 different types of blood cells in the body.\u003cbr\u003eThese are red blood cells, which bring oxygen to the tissues and organs, white blood cells, which fight infections, and platelets, which promote blood clotting to stop bleeding.\u003cbr\u003eIt is normal for the blood cells to die.\u003cbr\u003eIf the bone marrow is not replacing dead blood cells, the person will have bone marrow failure\u003cbr\u003eFA is a very severe disease and has permanent complications, which may be:\u003cbr\u003e1.Anemia\u003cbr\u003e2.Birth Defects of bone, eye, ear, skin, kidney and heart\u003cbr\u003e3.Cancer especially leukemia and mouth cancers\u003cbr\u003eFA is a recessive gene disorder.\u003cbr\u003eThis indicates the parents both have to have the defective FA gene for a person to develop FA\u003cbr\u003eAbnormalities in those 19 genes are responsible for 95 % of FA cases.\u003cbr\u003eIt is the most frequent of a group of relatively rare diseases called the inherited bone marrow failure syndromes (IBMFS).\u003cbr\u003eThe disorder is most often diagnosed in children between 2 and 15 years old.\u003cbr\u003eWhen a person does not have a sufficient number of blood cells he or she will begin to experience:\u003cbr\u003e1. Aplastic Anemia\u003cbr\u003eThe symptoms of anemia are:\u003cbr\u003ea. Dizziness,\u003cbr\u003eb. Headaches, and\u003cbr\u003ec. An inability to keep the hands and feet warm.\u003cbr\u003e2. Birth Defects\u003cbr\u003eCertain types of birth defects will indicate that the infant has FA, such as:\u003cbr\u003ea. Bone defects, especially involving the thumbs and arms\u003cbr\u003eb. Eye and ear defects\u003cbr\u003ec. Skin discoloration\u003cbr\u003ed. Kidney problems\u003cbr\u003ee. Congenital heart defects\u003cbr\u003e3. Developmental Problems\u003cbr\u003eDevelopmental problems can be:\u003cbr\u003ea. Low birth weight\u003cbr\u003eb. Poor appetite\u003cbr\u003ec. Delayed growth\u003cbr\u003ed. A smaller-than-normal height\u003cbr\u003ee. A smaller-than-normal head size\u003cbr\u003ef. Intellectual disability\u003cbr\u003eSymptoms in Adults\u003cbr\u003eAdults who are diagnosed later in life will normally have a completely different set of symptoms.\u003cbr\u003eThe symptoms in adults will normally involve the sexual organs or the reproductive system.\u003cbr\u003eThe symptoms in women are:\u003cbr\u003e1. Periods that occur later than normal\u003cbr\u003e2. Fertility issues\u003cbr\u003e3. Frequent miscarriages\u003cbr\u003e4. Early menopause\u003cbr\u003e5. Smaller-than-normal genitals\u003cbr\u003eMen with FA may have:\u003cbr\u003e1. Fertility issues and\u003cbr\u003e2. Smaller-than-normal genitals.\u003cbr\u003ePeople with Fanconi anemia have less numbers of white blood cells, red blood cells, and platelets (cells that help the blood clot).\u003cbr\u003eNot enough white blood cells can result in infections.\u003cbr\u003eA lack of red blood (anemia) cells may result in fatigue.\u003cbr\u003eThe lesser amount of platelets may lead to excessive bleeding.\u003cbr\u003eWomen who have a family history of FA should have genetic testing of their unborn baby.\u003cbr\u003eThis can be done through amniocentesis and chorionic villus sampling (CVS).\u003cbr\u003eChromosome breakage studies can also be done using CVS.\u003cbr\u003eIf the child tests positive for the FA gene, they will be monitored for other signs of the disorder.\u003cbr\u003eBone marrow biopsy or aspiration shows progressively hypo-cellular marrow with loss of myeloid and erythroid precursors and megakaryocytes, ultimately becoming typical of aplastic anemia\u003cbr\u003eFull blood count (FBC) may show macrocytosis with mild anemia through to pan-cytopenia.\u003cbr\u003eInitial presentation may be with isolated thrombocytopenia or leucopenia\u003cbr\u003eThe symptoms of FA can be treated but there is no cure for FA.\u003cbr\u003ePeople with mild to moderate blood cell changes do not need a transfusion\u003cbr\u003eMedicines called growth factors (such as erythropoietin, G-CSF, and GM-CSF) can improve blood counts\u003cbr\u003eA bone marrow transplant can cure blood count of FA\u003cbr\u003eMost people respond to hormone therapy.\u003c\/p\u003e\u003cp\u003eTABLE OF CONTENT\u003cbr\u003eIntroduction\u003cbr\u003eChapter 1 Fanconi Anemia\u003cbr\u003eChapter 2 Causes\u003cbr\u003eChapter 3 Symptoms\u003cbr\u003eChapter 4 Diagnosis\u003cbr\u003eChapter 5 Treatment\u003cbr\u003eChapter 6 Prognosis\u003cbr\u003eChapter 7 Aplastic Anemia\u003cbr\u003eChapter 8 Hemolytic Anemia\u003cbr\u003eEpilogue\u003c\/p\u003e","brand":"Kenneth Kee","offers":[{"title":"Default Title","offer_id":47103568609520,"sku":"2940154429259","price":2.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0737\/7593\/9824\/files\/2940154429259_p0.jpg?v=1764066321","url":"https:\/\/shop-qa.barnesandnoble.com\/products\/2940154429259","provider":"Barnes \u0026 Noble (DEV)","version":"1.0","type":"link"}