{"product_id":"9780081001059","title":"A Practical Guide to Rational Drug Design","description":"\u003cp\u003eThis book is not going to be an exhaustive survey covering all aspects of rational drug design. Instead, it is going to provide critical know-how through real-world examples. Relevant case studies will be presented and analyzed to illustrate the following: how to optimize a lead compound whether one has high or low levels of structural information; how to derive hits from competitors’ active compounds or from natural ligands of the targets; how to springboard from competitors’ SAR knowledge in lead optimization; how to design a ligand to interfere with protein-protein interactions by correctly examining the PPI interface; how to circumvent IP blockage using data mining; how to construct and fully utilize a knowledge-based molecular descriptor system; how to build a reliable QSAR model by focusing on data quality and proper selection of molecular descriptors and statistical approaches. \u003ci\u003eA Practical Guide to Rational Drug Design\u003c\/i\u003e focuses on computational drug design, with only basic coverage of biology and chemistry issues, such as assay design, target validation and synthetic routes.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eDiscusses various tactics applicable to daily drug design \u003c\/li\u003e\n\u003cli\u003eReaders can download the materials used in the book, including structures, scripts, raw data, protocols, and codes, making this book suitable resource for short courses or workshops\u003c\/li\u003e\n\u003cli\u003eOffers a unique viewpoint on drug discovery research due to the author’s cross-discipline education background \u003c\/li\u003e\n\u003cli\u003eExplores the author’s rich experiences in both pharmaceutical and academic settings\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Elsevier Science","offers":[{"title":"Default Title","offer_id":47153761714416,"sku":"9780081001059","price":210.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0737\/7593\/9824\/files\/9780081001059_p0.jpg?v=1763638632","url":"https:\/\/shop-qa.barnesandnoble.com\/products\/9780081001059","provider":"Barnes \u0026 Noble (DEV)","version":"1.0","type":"link"}