{"product_id":"9780123813275","title":"Basic Aspects of Catechol-O-Methyltransferase and the Clinical Applications of its Inhibitors","description":"Volume 95 of \u003ci\u003eInternational Review of Neurobiology\u003c\/i\u003e focuses on Catechol-O-methyltransferase inhibition, and its clinical application in relation to Parkinson’s disease. Chapters cover COMT gene and proteins, L-dopa treatment in Parkinson’s disease, the latest research on COMT inhibitors and their clinical applications, as well as future prospects for their use.\u003cul\u003e\n\u003cli\u003eUp-to-date summary of biochemistry and pharmacology of COMT and its inhibitors\u003c\/li\u003e\n\u003cli\u003ePreclinical models in COMT inhibitor devlopment\u003c\/li\u003e\n\u003cli\u003eTransgenic COMT mice – latest information summarized\u003c\/li\u003e\n\u003cli\u003eChemistry of COMT inhibitors and their design with molecular modelling\u003c\/li\u003e\n\u003cli\u003eCOMT gene and its regulation and relation to dopamine related diseases\u003c\/li\u003e\n\u003cli\u003eRole of cofactor SAM regulation in relation to homocysteine\u003c\/li\u003e\n\u003cli\u003eNonclinical and clinical safety of COMT inhibitors summarized\u003c\/li\u003e\n\u003cli\u003eFuture prospects of COMT inhibitors in Parkinson’s disease\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Elsevier Science","offers":[{"title":"Default Title","offer_id":47077223268592,"sku":"9780123813275","price":204.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0737\/7593\/9824\/files\/9780123813275_p0.jpg?v=1763639257","url":"https:\/\/shop-qa.barnesandnoble.com\/products\/9780123813275","provider":"Barnes \u0026 Noble (DEV)","version":"1.0","type":"link"}