{"product_id":"9780124186828","title":"The Synapse: Structure and Function","description":"\u003cp\u003e\u003ci\u003eThe Synapse\u003c\/i\u003e summarizes recent advances in cellular and molecular mechanisms of synaptic transmission and provides new insights into neuronal plasticity and the cellular basis of neurological diseases. \u003c\/p\u003e \u003cul\u003e\n\u003cli\u003ePart 1 provides an in-depth look at structural differences and distribution of various pre- and post-synaptic proteins found at glutamatergic synapses.\u003c\/li\u003e\n\u003cli\u003ePart 2 is dedicated to dendritic spines and their associated perisynaptic glia, which together constitute the tripartite synapse. The spines are portrayed as major sites for calcium sequestration and local protein synthesis.\u003c\/li\u003e\n\u003cli\u003ePart 3 highlights the important regional and cellular differences between glutamatergic transmission and that of neurotransmitters such as dopamine and acetylcholine that are commonly found in axon terminals without synaptic membrane specializations.\u003c\/li\u003e\n\u003cli\u003ePart 4 provides an overview of the synapse from the time of formation to degeneration under the powerful influence of aging or hormonal decline that leads to severe deficits in cognitive function.\u003c\/li\u003e\n\u003c\/ul\u003e \u003cp\u003eEach chapter is illustrated with drawings and images derived from calcium imaging, electron microscopic immunolabeling, or electrophysiology. This book is a valuable reference for neuroscientists and clinical neurologists in both research and clinical settings.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eA comprehensive reference focused on the structure and function of the synapse\u003c\/li\u003e\n\u003cli\u003eCovers the links between the synapse and neural plasticity and the cellular basis of neurologic disease\u003c\/li\u003e\n\u003cli\u003eDetailed coverage of dendritic spines and associated perisynaptic glia—the tripartite synapse\u003c\/li\u003e\n\u003cli\u003eIncludes in-depth coverage of synapse degeneration due to aging or hormonal decline related to severe cognitive impairment\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Elsevier Science","offers":[{"title":"Default Title","offer_id":47153735401712,"sku":"9780124186828","price":127.49,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0737\/7593\/9824\/files\/9780124186828_p0.jpg?v=1763639147","url":"https:\/\/shop-qa.barnesandnoble.com\/products\/9780124186828","provider":"Barnes \u0026 Noble (DEV)","version":"1.0","type":"link"}