{"product_id":"9780127999203","title":"DNA Methylation and Complex Human Disease","description":"\u003cp\u003e\u003ci\u003eDNA Methylation and Complex Human Disease\u003c\/i\u003e reviews the possibilities of methyl-group-based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future uses of high-throughput methylome technologies. \u003c\/p\u003e \u003cp\u003eThis volume includes many pertinent advances in disease-bearing research, including obesity, type II diabetes, schizophrenia, and autoimmunity. DNA methylation is also discussed as a plasma and serum test for non-invasive screening, diagnostic and prognostic tests, as compared to biopsy-driven gene expression analysis, factors which have led to the use of DNA methylation as a potential tool for determining cancer risk, and diagnosis between benign and malignant disease.\u003c\/p\u003e \u003cp\u003eTherapies are at the heart of this volume and the possibilities of DNA demethylation. In cancer, unlike genetic mutations, DNA methylation and histone modifications are reversible and thus have shown great potential in the race for effective treatments. In addition, the authors present the importance of high-throughput methylome analysis, not only in cancer, but also in non-neoplastic diseases such as rheumatoid arthritis.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eDiscusses breaking biomarker research in major disease families of current health concern and research interest, including obesity, type II diabetes, schizophrenia, and autoimmunity\u003c\/li\u003e\n\u003cli\u003eSummarizes advances not only relevant to cancer, but also in non-neoplastic disease, currently an emerging field\u003c\/li\u003e\n\u003cli\u003eDescribes wholly new concepts, including the linking of metabolic pathways with epigenetics\u003c\/li\u003e\n\u003cli\u003eProvides translational researchers with the knowledge of both basic research and clinic applications of DNA methylation in human diseases\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Elsevier Science","offers":[{"title":"Default Title","offer_id":47071509545200,"sku":"9780127999203","price":125.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0737\/7593\/9824\/files\/9780127999203_p0.jpg?v=1763639090","url":"https:\/\/shop-qa.barnesandnoble.com\/products\/9780127999203","provider":"Barnes \u0026 Noble (DEV)","version":"1.0","type":"link"}