{"product_id":"9780128004999","title":"Molecular Targets in Protein Misfolding and Neurodegenerative Disease","description":"\u003cp\u003eAimed at \"drug discoverers\" – i.e. any scientist who is interested in neurodegenerative diseases in general, and in finding disease-modifying treatments in particular – the first edition of \u003ci\u003eMolecular Targets in Protein Misfolding and Neurodegenerative Disease\u003c\/i\u003e will contain both a detailed, discipline-specific coverage (paragraphs on medicinal chemistry, on clinical and preclinical characterization of compounds in development, on target identification and validation, on genetic factors influencing a pathology, etc.) and a drug discovery-oriented, overall evaluation of each target (validation, druggability, existing leads, etc.). Together these will satisfy the needs of various audiences, including \u003ci\u003ein vitro\u003c\/i\u003e biologists, pharmacologists, medicinal chemists, etc.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eWritten to provide a comprehensive coverage of disease-modifying mechanisms and compounds against neurodegenerative diseases\u003c\/li\u003e\n\u003cli\u003eProvides a “drug discovery” application oriented perspective, evaluating targets and candidates for their overall therapeutic potential\u003c\/li\u003e\n\u003cli\u003eProvides discipline-specific chapters (medicinal chemistry, target validation, preclinical and clinical development\u003c\/li\u003e\n\u003cli\u003eProvides an overview on a number of molecular mechanisms (e.g. phosphorylation, chaperon refolding, ubiquitination, autophagy, microtubule transportation, protease cleavage, etc.) with relevance for any disease area\u003c\/li\u003e\n\u003cli\u003eContains a more thorough description of the therapeutic relevance of ~10 specific molecular targets\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Elsevier Science","offers":[{"title":"Default Title","offer_id":47079779893488,"sku":"9780128004999","price":123.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0737\/7593\/9824\/files\/9780128004999_p0.jpg?v=1763639554","url":"https:\/\/shop-qa.barnesandnoble.com\/products\/9780128004999","provider":"Barnes \u0026 Noble (DEV)","version":"1.0","type":"link"}