{"product_id":"9780128019597","title":"Chemical Modulators of Protein Misfolding and Neurodegenerative Disease","description":"\u003cp\u003eThis book is a neurochemistry-based companion for \u003ci\u003eProtein Misfolding and Neurodegenerative Diseases: Molecular Targets\u003c\/i\u003e, an Elsevier title by the same author publishing in December 2014. While the first book focuses on biology and molecular targets, this companion book describes how these targets are regulated by small molecules and disease-modifying compounds. The book begins with a brief introduction to how key proteins become dysfunctional, and each subsequent chapter describes major disease mechanisms in Alzheimer’s and other tauopathies. Properties and development status of these molecular targets and disease mechanisms are thoroughly described, as are small molecule effectors of autophagy and dis-aggregating agents. \u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eWritten to provide comprehensive coverage of neurodegenerative disease-modifying compounds\u003c\/li\u003e\n\u003cli\u003eProvides discipline-specific chapters that cover medicinal chemistry and clinical applications\u003c\/li\u003e\n\u003cli\u003eProvides an overview of more than 200 chemical classes and lead compounds, acting on selected molecular targets that are of relevance to any neurodegenerative disorder\u003c\/li\u003e\n\u003cli\u003eCoverage of misfolding diseases, chaperone proteins, ubiquitination and autophagy\/oncology makes this book suitable for structural neurochemists, chemists, biologists, non-CNS scientists, and scientists interested in drug discovery\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Elsevier Science","offers":[{"title":"Default Title","offer_id":47077744607472,"sku":"9780128019597","price":84.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0737\/7593\/9824\/files\/9780128019597_p0.jpg?v=1763640679","url":"https:\/\/shop-qa.barnesandnoble.com\/products\/9780128019597","provider":"Barnes \u0026 Noble (DEV)","version":"1.0","type":"link"}