{"product_id":"9780128033227","title":"The Origin of Chronic Inflammatory Systemic Diseases and their Sequelae","description":"\u003cp\u003eChronic inflammatory diseases such as rheumatoid arthritis, ankylosing spondylitis, multiple sclerosis, inflammatory bowel diseases, and others typically stimulate a systemic response of the entire body. This response has a uniform character in many diseases because common pathways are switched on. The uniform response regulates systemic energy and water provision. However, long-term application of this program leads to typical disease sequelae such as fatigue \/ depressive symptoms, sleep disturbances, anorexia, malnutrition, muscle wasting – cachexia, cachectic obesity, insulin resistance, dyslipidemia, alterations of steroid hormone axes, disturbances of the hypothalamic-pituitary-gonadal axis, elevated sympathetic tone, hypertension, volume expansion, decreased parasympathetic tone, inflammation–related anemia, bone loss, hypercoagulability, circadian rhythms of symptoms, and disease exacerbation by stress .\u003ci\u003e \u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eThe Origin of Chronic Inflammatory Systemic Diseases\u003c\/i\u003e \u003ci\u003eand Their Sequelae \u003c\/i\u003edemonstrates concepts of neuroendocrine immunology, energy and water regulation, and evolutionary medicine in order to show that the uniform response that regulates systemic energy and water provision, has been positively selected for acute physiological responses and short-lived disease states, but is a misguided program in chronic inflammatory diseases and aging.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eOffers a broad conceptual framework with a strong clinical link, written in an easy to grasp style and demonstrating the link to aging research\u003c\/li\u003e\n\u003cli\u003eDescribes the important principles derived from basic immunology that are used to explain pathogenesis of chronic inflammatory systemic diseases with a focus on autoimmunity\u003c\/li\u003e\n\u003cli\u003eDefines the bioenergetics and energy regulation of the body explaining common response pathways typical for systemic inflammation\u003c\/li\u003e\n\u003cli\u003eMakes use of evolutionary medicine theory to demonstrate the uniformity of the systemic response\u003c\/li\u003e\n\u003cli\u003eExplains the appearance of typical disease sequelae on the basis of the three pillars: neuroendocrine immunology, energy regulation, and evolutionary medicine theory\u003c\/li\u003e\n\u003cli\u003eContains color figures and tables that explain the field to newcomers\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Elsevier Science","offers":[{"title":"Default Title","offer_id":47124155531504,"sku":"9780128033227","price":140.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0737\/7593\/9824\/files\/9780128033227_p0.jpg?v=1763640845","url":"https:\/\/shop-qa.barnesandnoble.com\/products\/9780128033227","provider":"Barnes \u0026 Noble (DEV)","version":"1.0","type":"link"}