{"product_id":"9781118553510","title":"Metal-Based Neurodegeneration: From Molecular Mechanisms to Therapeutic Strategies","description":"\u003cp\u003eNeurodegenerative diseases of the human brain appear in various forms, resulting in disorders of movement and coordination, cognitive deterioration and psychiatric disturbances. Many of the key factors leading to neurodegenerative diseases are similar, including the dysfunction of metal ion homeostasis, redox-active metal ions generating oxidative stress, and intracellular inclusion bodies.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eMetal-based Neurodegeneration\u003c\/i\u003e presents a detailed survey of the molecular origins of neurodegenerative diseases. Each chapter is dedicated to a specific disease, presenting the latest scientific findings,  including details of their biochemical actors (proteins or peptides), their normal and pathological conformations, and a description of the diseases characteristics, with an emphasis on the role of metal-induced oxidative stress, which can result in the production of intracellular aggregates of target proteins and peptides. \u003c\/p\u003e \u003cp\u003eTopics covered include:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eBrain function, physiology and the blood-brain barrier\u003c\/li\u003e \u003cli\u003eImmune system and neuroinflammation\u003c\/li\u003e \u003cli\u003eAging and mild cognitive impairment, MCI\u003c\/li\u003e \u003cli\u003eParkinson’s Disease\u003c\/li\u003e \u003cli\u003eAlzheimer’s Disease\u003c\/li\u003e \u003cli\u003eCreutzfelt-Jakob and related prion diseases\u003c\/li\u003e \u003cli\u003eAlcoholic Brain Damage\u003c\/li\u003e \u003cli\u003eTherapeutic strategies to combat the onset and progression of neurological diseases\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eThis extensively updated, full colour, second edition of \u003ci\u003eMetal-based Neurodegeneration\u003c\/i\u003e is an essential text for research scientists and clinicians working in gerontology, neuropathology, neurochemistry, and metalloprotein mechanisms.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47107258876144,"sku":"9781118553510","price":207.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0737\/7593\/9824\/files\/9781118553510_p0.jpg?v=1769888749","url":"https:\/\/shop-qa.barnesandnoble.com\/products\/9781118553510","provider":"Barnes \u0026 Noble (DEV)","version":"1.0","type":"link"}