{"product_id":"9781118580912","title":"Antibiotics and Bacterial Resistance","description":"\u003cp\u003eThe need for novel antibiotics is greater now than perhaps any time since the pre-antibiotic era. Indeed, the recent collapse of many pharmaceutical antibacterial groups, combined with the emergence of hypervirulent and pan-antibiotic-resistant bacteria has severely compromised infection treatment options and led to dramatic increases in the incidence and severity of bacterial infections.\u003c\/p\u003e \u003cp\u003eThis collection of reviews and laboratory protocols gives the reader an introduction to the causes of antibiotic resistance, the bacterial strains that pose the largest danger to humans (i.e., streptococci, pneumococci and enterococci) and the antimicrobial agents used to combat infections with these organisms. Some new avenues that are being investigated for antibiotic development are also discussed. Such developments include the discovery of agents that inhibit bacterial RNA degradation, the bacterial ribosome, and structure-based approaches to antibiotic drug discovery.\u003c\/p\u003e \u003cp\u003eTwo laboratory protocols are provided to illustrate different strategies for discovering new antibiotics. One is a bacterial growth inhibition assay to identify inhibitors of bacterial growth that specifically target conditionally essential enzymes in the pathway of interest. The other protocol is used to identify inhibitors of bacterial cell-to-cell signaling.\u003c\/p\u003e \u003cp\u003eThis e-book — a curated collection from eLS, WIREs, and Current Protocols — offers a fantastic introduction to the field of antibiotics and antibiotic resistance for students or interdisciplinary collaborators.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eTable of Contents:\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eIntroduction\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eAntibiotics and the Evolution of Antibiotic Resistance\u003cbr\u003e \u003ci\u003eeLS\u003c\/i\u003e\u003cbr\u003e Jose L Martinez, Fernando Baquero\u003c\/p\u003e \u003cp\u003eAntimicrobials Against Streptococci, Pneumococci and Enterococci\u003cbr\u003e \u003ci\u003eeLS\u003c\/i\u003e\u003cbr\u003e Susan Donabedian, Adenike Shoyinka\u003c\/p\u003e \u003cp\u003e\u003cb\u003eTechniques\u0026amp;Applications\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eRNA decay: a novel therapeutic target in bacteria\u003cbr\u003e \u003ci\u003eWIREs RNA\u003c\/i\u003e\u003cbr\u003e Tess M. Eidem, Christelle M. Roux, Paul M. Dunman\u003c\/p\u003e \u003cp\u003eAntibiotics that target protein synthesis\u003cbr\u003e \u003ci\u003eWIREs RNA\u003c\/i\u003e\u003cbr\u003e Lisa S. McCoy, Yun Xie, Yitzhak Tor\u003c\/p\u003e \u003cp\u003e\u003cb\u003eMethods\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eHigh-Throughput Assessment of Bacterial Growth Inhibition by Optical Density Measurements\u003cbr\u003e \u003ci\u003eCurrent Protocols Chemical Biology\u003c\/i\u003e\u003cbr\u003e Jennifer Campbell\u003c\/p\u003e \u003cp\u003eStructure-Based Approaches to Antibiotic Drug Discovery\u003cbr\u003e \u003ci\u003eCurrent Protocols Microbiology\u003c\/i\u003e\u003cbr\u003e George Nicola, Ruben Abagyan\u003c\/p\u003e \u003cp\u003eNovel Approaches to Bacterial Infection Therapy by Interfering with Cell-to-Cell Signaling\u003cbr\u003e \u003ci\u003eCurrent Protocols Microbiology\u003c\/i\u003e\u003cbr\u003e David A. Rasko, Vanessa Sperandio\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47078316441840,"sku":"9781118580912","price":34.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0737\/7593\/9824\/files\/9781118580912_p0.jpg?v=1763694881","url":"https:\/\/shop-qa.barnesandnoble.com\/products\/9781118580912","provider":"Barnes \u0026 Noble (DEV)","version":"1.0","type":"link"}