{"product_id":"9781118734391","title":"Epigenetics in Cancer","description":"\u003cp\u003eEpigenetics is the study of heritable changes in gene expression or cellular phenotype, caused by mechanisms other than changes in the DNA sequence. Examples include DNA methylation and histone modification. These changes may remain through cell divisions and multiple generations. Epigenetic differences among individuals may account for some of the differences between monozygotic (identical) twins. Aberrant DNA methylation is also frequently associated with human aging and diseases, such as cancer.\u003c\/p\u003e \u003cp\u003eThis collection of overviews and laboratory protocols provides crucial, distilled information about the roles of epigenetics in cancer development. The overviews are geared for research scientists who need to learn more about the current understanding of epigenetic variation in humans and how the processes of DNA methylation and histone modification are regulated. The protocols give step-by-step instructions on how to detect DNA methylation using various methods such as MAPit, CHARM (arrays) and methylation-specific PCR.\u003c\/p\u003e \u003cp\u003eThis e-book — a curated collection from eLS, WIREs, and Current Protocols — offers a fantastic introduction to the fields of genetics, genomics, and oncogenesis for students or interdisciplinary collaborators.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eTable of Contents:\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eIntroduction\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eEpigenetic Variation in Humans\u003cbr\u003e \u003ci\u003eeLS\u003c\/i\u003e\u003cbr\u003e Jon F. Wilkins\u003c\/p\u003e \u003cp\u003eGenetic and Epigenetic Heterogeneity in Cancer\u003cbr\u003e \u003ci\u003eeLS\u003c\/i\u003e\u003cbr\u003e Joshua B. Stevens, Batoul Y. Abdallah, Steven D. Horne, Guo Liu, Steven W. Bremer and Henry H. Heng\u003c\/p\u003e \u003cp\u003e\u003cb\u003eTechniques\u0026amp;Applications\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eMediators and Dynamics of DNA Methylation\u003cbr\u003e \u003ci\u003eWIREs Systems Biology and Medicine\u003c\/i\u003e\u003cbr\u003e Robert Shoemaker, Wei Wang and Kun Zhang\u003c\/p\u003e \u003cp\u003eDNA Methylation Alterations in Multiple Myeloma as a Model for Epigenetic Changes in Cancer\u003cbr\u003e \u003ci\u003eWIREs Systems Biology and Medicine\u003c\/i\u003e\u003cbr\u003e Amy Sharma, Christoph J. Heuck, Melissa J. Fazzari, Jayesh Mehta, Seema Singhal, John M. Greally and Amit Verma\u003c\/p\u003e \u003cp\u003e\u003ci\u003eInk4?-Arf\u003c\/i\u003e Locus in Cancer and Aging\u003cbr\u003e \u003ci\u003eWIREs Developmental Biology\u003c\/i\u003e\u003cbr\u003e Charles J. Sherr\u003c\/p\u003e \u003cp\u003e\u003cb\u003eProtocols\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eSimultaneous Single-Molecule Mapping of Protein-DNA Interactions and DNA Methylation by MAPit\u003cbr\u003e \u003ci\u003eCurrent Protocols in Molecular Biology\u003c\/i\u003e\u003cbr\u003e Carolina E. Pardo, Russell P. Darst, Nancy H. Nabilsi, Amber L. Delmas and Michael P. Kladde\u003c\/p\u003e \u003cp\u003eComprehensive High-Throughput Arrays for Relative Methylation (CHARM)\u003cbr\u003e \u003ci\u003eCurrent Protocols in Human Genetics\u003c\/i\u003e\u003cbr\u003e Christine Ladd-Acosta, Martin J. Aryee, Jared M. Ordway and Andrew P. Feinberg\u003c\/p\u003e \u003cp\u003eMethylation-specific PCR\u003cbr\u003e \u003ci\u003eCurrent Protocols in Human Genetics\u003c\/i\u003e\u003cbr\u003e Bradford Coffee\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47136390611184,"sku":"9781118734391","price":34.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0737\/7593\/9824\/files\/9781118734391_p0.jpg?v=1763695176","url":"https:\/\/shop-qa.barnesandnoble.com\/products\/9781118734391","provider":"Barnes \u0026 Noble (DEV)","version":"1.0","type":"link"}