{"product_id":"9781118788493","title":"Blood-Brain Barrier in Drug Discovery: Optimizing Brain Exposure of CNS Drugs and Minimizing Brain Side Effects for Peripheral Drugs","description":"\u003cp\u003eFocused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most significant – and most challenging – areas of drug discovery.\u003c\/p\u003e \u003cp\u003e• Written by world experts to provide practical solutions to increase brain penetration or minimize CNS side-effects\u003cbr\u003e • Reviews state-of-the-art in silico, in vitro, and in vivo tools to assess brain penetration and advanced CNS drug delivery strategies\u003cbr\u003e • Covers BBB physiology, medicinal chemistry design principles, free drug hypothesis for the BBB, and transport mechanisms including passive diffusion, uptake\/efflux transporters, and receptor-mediated processes\u003cbr\u003e • Highlights the advances in modelling BBB pharmacokinetics and dynamics relationships (PK\/PD) and physiologically-based pharmacokinetics (PBPK)\u003cbr\u003e • Discusses case studies of successful CNS and non-CNS drugs, lessons learned and paths to the market\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47120042819824,"sku":"9781118788493","price":155.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0737\/7593\/9824\/files\/9781118788493_p0.jpg?v=1769889415","url":"https:\/\/shop-qa.barnesandnoble.com\/products\/9781118788493","provider":"Barnes \u0026 Noble (DEV)","version":"1.0","type":"link"}