{"product_id":"9781119099505","title":"Applied Biophysics for Drug Discovery","description":"\u003cp\u003e\u003ci\u003eApplied Biophysics for Drug Discovery\u003c\/i\u003e is a guide to new techniques and approaches to identifying and characterizing small molecules in early drug discovery. Biophysical methods are reasserting their utility in drug discovery and through a combination of the rise of fragment-based drug discovery and an increased focus on more nuanced characterisation of small molecule binding, these methods are playing an increasing role in discovery campaigns. \u003c\/p\u003e \u003cp\u003eThis text emphasizes practical considerations for selecting and deploying core biophysical method, including but not limited to ITC, SPR, and both ligand-detected and protein-detected NMR.\u003c\/p\u003e \u003cp\u003eTopics covered include:\u003c\/p\u003e \u003cp\u003e•          Design considerations in biophysical-based lead screening\u003c\/p\u003e \u003cp\u003e•          Thermodynamic characterization of protein-compound interactions\u003c\/p\u003e \u003cp\u003e•          Characterizing targets and screening reagents with HDX-MS\u003c\/p\u003e \u003cp\u003e•          Microscale thermophoresis methods (MST)\u003c\/p\u003e \u003cp\u003e•          Screening with Weak Affinity Chromatography\u003c\/p\u003e \u003cp\u003e•          Methods to assess compound residence time\u003c\/p\u003e \u003cp\u003e•          1D-NMR methods for hit identification\u003c\/p\u003e \u003cp\u003e•          Protein-based NMR methods for SAR development\u003c\/p\u003e \u003cp\u003e•          Industry case studies integrating multiple biophysical methods\u003c\/p\u003e \u003cp\u003eThis text is ideal for academic investigators and industry scientists planning hit characterization campaigns or designing and optimizing screening strategies.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47134462476528,"sku":"9781119099505","price":150.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0737\/7593\/9824\/files\/9781119099505_p0.jpg?v=1763696631","url":"https:\/\/shop-qa.barnesandnoble.com\/products\/9781119099505","provider":"Barnes \u0026 Noble (DEV)","version":"1.0","type":"link"}