{"product_id":"9781119957218","title":"Protein Surface Recognition: Approaches for Drug Discovery","description":"A new perspective on the design of molecular therapeutics is emerging. This new strategy emphasizes the rational complementation of functionality along extended patches of a protein surface with the aim of inhibiting protein\/protein interactions. The successful development of compounds able to inhibit these interactions offers a unique chance to selectively intervene in a large number of key cellular processes related to human disease. \u003cp\u003e\u003ci\u003eProtein Surface Recognition\u003c\/i\u003e presents a detailed treatment of this strategy, with topics including:\u003c\/p\u003e \u003cul\u003e \u003cli\u003ean extended survey of protein-protein interactions that are key players in human disease and biology and the potential for therapeutics derived from this new perspective\u003c\/li\u003e \u003cli\u003ethe fundamental physical issues that surround protein-protein interactions that must be considered when designing ligands for protein surfaces\u003c\/li\u003e \u003cli\u003eexamples of protein surface-small molecule interactions, including treatments of protein-natural product interactions, protein-interface peptides, and rational approaches to protein surface recognition from model to biological systems\u003c\/li\u003e \u003cli\u003ea survey of techniques that will be integral to the discovery of new small molecule protein surface binders, from high throughput synthesis and screening techniques to \u003ci\u003ein silico\u003c\/i\u003e and \u003ci\u003ein vitro\u003c\/i\u003e methods for the discovery of novel protein ligands.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e\u003ci\u003eProtein Surface Recognition\u003c\/i\u003e provides an intellectual “tool-kit” for investigators in medicinal and bioorganic chemistry looking to exploit this emerging paradigm in drug discovery.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47107343778032,"sku":"9781119957218","price":182.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0737\/7593\/9824\/files\/9781119957218_p0.jpg?v=1769890718","url":"https:\/\/shop-qa.barnesandnoble.com\/products\/9781119957218","provider":"Barnes \u0026 Noble (DEV)","version":"1.0","type":"link"}