{"product_id":"9781461412212","title":"Caveolins and Caveolae: Roles in Signaling and Disease Mechanisms","description":"\u003cp\u003eCaveolae are 50-100 nm flask-shaped invaginations of the plasma membrane that are primarily composed of cholesterol and sphingolipids. Using modern electron microscopy techniques, caveolae can be observed as omega-shaped invaginations of the plasma membrane, fully-invaginated caveolae, grape-like clusters of interconnected caveolae (caveosome), or as transcellular channels as a consequence of the fusion of individual caveolae. The caveolin gene family consists of three distinct members, namely Cav-1, Cav-2 and Cav-3. Cav-1 and Cav-2 proteins are usually co-expressed and particularly abundant in epithelial, endothelial, and smooth muscle cells as well as adipocytes and fibroblasts. On the other hand, the Cav-3 protein appears to be muscle-specific and is therefore only expressed in smooth, skeletal and cardiac muscles. Caveolin proteins form high molecular weight homo- and\/or hetero-oligomers and assume an unusual topology with both their N- and C-terminal domains facing the cytoplasm.\u003c\/p\u003e","brand":"Springer New York","offers":[{"title":"Default Title","offer_id":47060501201136,"sku":"9781461412212","price":219.99,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0737\/7593\/9824\/files\/9781461412212_p0.jpg?v=1763673623","url":"https:\/\/shop-qa.barnesandnoble.com\/products\/9781461412212","provider":"Barnes \u0026 Noble (DEV)","version":"1.0","type":"link"}