{"product_id":"9781461425243","title":"Cancer Genome and Tumor Microenvironment","description":"\u003cp\u003eOncogenes and tumor suppressor genes had been traditionally studied in the context of cell proliferation, differentiation, senescence, and survival, four relatively cell-autonomous processes. Consequently, in the late ‘80s-mid ‘90s, neoplastic growth was described largely as a net imbalance between cell accumulation and loss, brought about through mutations in cancer genes. In the last ten years, a more holistic understanding of cancer slowly emerged, stressing the importance of interactions between neoplastic and various stromal components: extracellular matrix, basement membranes, fibroblasts, endothelial cells of blood and lymphatic vessels, tumor-infiltrating lymphocytes, etc . Nevertheless, the commonly held view is that changes in tumor microenvironment are \"soft-wired\", i.e. epigenetic in nature and often reversible. Yet, there exists a large body of evidence suggesting that well-known mutations in cancer genes profoundly affect tumor milieu. In fact, these cell-extrinsic changes might be one of the primary reasons such mutations are preserved in late-stage tumors. Cancer Genome and Tumor Microenvironment reviews how tumor microenvironment and progression can be \"hard-wired\", i.e. genetically controlled.\u003c\/p\u003e","brand":"Springer New York","offers":[{"title":"Default Title","offer_id":47053773504752,"sku":"9781461425243","price":279.99,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0737\/7593\/9824\/files\/9781461425243_p0.jpg?v=1763673746","url":"https:\/\/shop-qa.barnesandnoble.com\/products\/9781461425243","provider":"Barnes \u0026 Noble (DEV)","version":"1.0","type":"link"}