{"product_id":"9781461448143","title":"Microdialysis in Drug Development","description":"\u003cp\u003eIn vivo target site concentrations are probably the most important determinant of drug effects. Traditionally, linking drug concentrations to drug effects has been accomplished by modelling blood-derived data, mostly because a direct quantification of tissue concentrations has been beyond technical reach. Today, a direct measurement of target site concentrations is possible by employing microdialysis or complementary approaches such as imaging technologies. Microdialysis, initially conceived in the 1970ies, has become a standard tool in drug development. This comprehensive overview of current microdialysis technology covers general and disease-specific aspects of microdialysis by international experts in the field. It provides useful information for colleagues in academia and industry who are interested PK-PD aspects of drug development.\u003c\/p\u003e","brand":"Springer New York","offers":[{"title":"Default Title","offer_id":47053775503600,"sku":"9781461448143","price":219.99,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0737\/7593\/9824\/files\/9781461448143_p0.jpg?v=1763673915","url":"https:\/\/shop-qa.barnesandnoble.com\/products\/9781461448143","provider":"Barnes \u0026 Noble (DEV)","version":"1.0","type":"link"}