{"product_id":"9781461482888","title":"Gadd45 Stress Sensor Genes","description":"Emerging evidence indicates that the Gadd45 family of genes play a unique and critical role as sensors of stress, including genotoxic, physiological and oncogenic stress. The stress response Gadd45 family of genes (Gadd45a, Gadd45b \u0026amp; Gadd45g), discovered by Dr. Liebermann and other researchers, encode for small (18 kd) nuclear\/cytoplasmic proteins). These genes are rapidly induced by a wide variety of endogenous and exogenous stress stimuli. In spite of marked similarities, Gadd45 genes are regulated differently \u0026amp; exhibit functional diversity. Gadd45 are implicated in cell cycle arrest, DNA demethylation \u0026amp; repair, apoptosis, cell survival, genomic stability, inflammation, \u0026amp; in response to physiological and oncogenic stress. Functions of Gadd45 genes are mediated by protein-protein interactions that modulate structure\/function of other cellular proteins implicated in cell cycle regulation and the response of cells to stress; these interactions vary depending upon the biological setting including cell type, developmental stage and stress\/stimulus. Protein partners include cdc2\/cyclinB1, p21, the p38\/JNK stress induced kinase pathways, and PCNA\/histones. The purpose of this book is to provide a comprehensive picture of the unique global role Gadd45 genes play as stress sensors \u0026amp; the molecular pathways involved.","brand":"Springer New York","offers":[{"title":"Default Title","offer_id":47027125813488,"sku":"9781461482888","price":169.99,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0737\/7593\/9824\/files\/9781461482888_p0.jpg?v=1763674237","url":"https:\/\/shop-qa.barnesandnoble.com\/products\/9781461482888","provider":"Barnes \u0026 Noble (DEV)","version":"1.0","type":"link"}