{"product_id":"9781621820369","title":"The Biology of the Tgf- Family","description":"\u003cbr\u003eThe transforming growth factor ß (TGF-ß) family is a large group of structurally related proteins that drive developmental programs and control cell behavior. The TGF-ß family members exert their effects by binding to receptors on the cell surface, activating intracellular signaling pathways that modulate gene expression programs that control normal cell physiology, immune responses, and a variety of developmental processes. TGF-ß signaling is also important in conditions such as cancer, skeletal disorders, and cardiovascular diseases.\u003cp\u003eWritten and edited by experts in the field, this collection from \u003cem\u003eCold Spring Harbor Perspectives in Biology\u003c\/em\u003e provides a comprehensive view of the different members of the TGF-ß family, the signaling pathways they control, and how they influence development, normal physiology, and disease. The contributors describe the various TGF-ß family ligands, including activins and bone morphogenetic proteins (BMPs), the structures and functions of the type I and type II receptors, and how ligand-receptor binding is regulated. Both Smad and non-Smad signaling pathways are discussed, as is cross talk between TGF-ß and other signaling pathways (e.g., Wnt). Individual chapters are devoted to the roles of TGF-ß signaling in specific biological processes, including cell proliferation, mesenchymal differentiation, branching morphogenesis, stem cell biology, immunity, vascular function, reproduction, and neurobiology. The roles of TGF-ß signaling in cancer, fibrosis, skeletal diseases, and other conditions, as well as prospects for therapeutics, are also covered.\u003c\/p\u003e\u003cp\u003eThe authors also review TGF-ß signaling in model organisms (e.g., C. elegans and Drosophila), as well as the discovery of TGF-ß and early research in the field. This volume is therefore a comprehensive reference on the biology of the TGF-ß family, and it will be valuable for not only cell and developmental biologists but all who wish to learn about this important field of research.\u003cbr\u003e\u003c\/p\u003e","brand":"Cold Spring Harbor Laboratory Press","offers":[{"title":"Default Title","offer_id":47051930861808,"sku":"9781621820369","price":135.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0737\/7593\/9824\/files\/9781621820369_p0.jpg?v=1763858353","url":"https:\/\/shop-qa.barnesandnoble.com\/products\/9781621820369","provider":"Barnes \u0026 Noble (DEV)","version":"1.0","type":"link"}