{"product_id":"9781783263141","title":"Advanced Textbook on Gene Transfer, Gene Therapy and Genetic Pharmacology: Principles, Delivery and Pharmacological and Biomedical Applications of Nucleotide-Based Therapies","description":"\u003cp\u003eThis unique advanced textbook provides a clear and comprehensive description of the field of gene delivery, gene therapy and genetic pharmacology, with descriptions of the main gene transfer vectors and a set of selected therapeutic applications, along with safety considerations.\u003c\/p\u003e\u003cp\u003eThe use of gene transfer is exponentially growing in the scientific and medical communities for day-to-day cell biology experiments and swift development of revolutionary gene therapy  strategies. In this advanced textbook, more than 25 leading scientists, world-renowned in their respective fields, come together to provide a clear and comprehensive description of gene delivery, gene therapy and genetic pharmacology.\u003c\/p\u003e\u003cp\u003eThis educational introduction to the main gene transfer vectors and selected therapeutic applications provides the background material needed to further explore the subject as well as relevant research literature. It will thus be invaluable to Master, PhD or MD students, post-doctoral scientists or medical doctors, as well as any scientist wishing to deliver a gene or synthetic nucleotide, or develop a gene therapy strategy. Furthermore, the textbook's simple and synthetic content will be of value to any reader interested in the biological and medical revolution derived from the elucidation of the human genome.\u003c\/p\u003e\u003cb\u003eContents:\u003c\/b\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cb\u003e\u003ci\u003eBasic Definitions and Principles:\u003c\/i\u003e\u003c\/b\u003e\u003cul\u003e\n\u003cli\u003eIntroduction \u003ci\u003e(Thierry VandenDriessche)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eBasic Definitions and General Principles \u003ci\u003e(Daniel Scherman)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eHistory of Gene Therapy \u003ci\u003e(Serge Braun)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eGenetic Pharmacology Using Synthetic Deoxyribonucleotides \u003ci\u003e(Jean-Christophe François and Carine Giovannangeli)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003ePrinciples of RNAi Trigger Expression for Gene Therapy \u003ci\u003e(Lisa J Scherer and John J Rossi)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eOn Demand Alternative Splicing for Gene Rescue \u003ci\u003e(Stéphanie Lorain and Luis Garcia)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eNuclease-Mediated Targeted Genetic Correction \u003ci\u003e(Dieter C Gruenert, Hamid Emamekhoo and R Geoffrey Sargent)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003e\u003ci\u003eVectors and Gene Delivery Techniques:\u003c\/i\u003e\u003c\/b\u003e\u003cul\u003e\n\u003cli\u003eγ-Retrovirus- and Lentivirus-Derived Vectors for Gene Transfer and Therapy \u003ci\u003e(Caroline Duros and Odile Cohen-Haguenauer)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eAdenovirus Vectors \u003ci\u003e(Stefan Kochanek)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eAdeno-Associated Virus (AAV) Vectors \u003ci\u003e(Aurélie Ploquin, Hildegard Büning and Anna Salvetti)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eHerpes Simplex Virus (HSV-1)-Based Vectors: Applications for Gene Transfer, Gene Therapy, Cancer Virotherapy and Vaccination \u003ci\u003e(Matias E Melendez, Aldo Pourchet, Anna Greco and Alberto L Epstein)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eNon-Viral DNA Vectors \u003ci\u003e(Martin Schleef)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eMacromolecular Conjugates for Non-Viral Nucleic Acid Delivery \u003ci\u003e(Mark Ericson, Kevin Rice and Guy Zuber)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eAuto-Associative Lipid-Based Systems for Non-Viral Nucleic Acid Delivery \u003ci\u003e(Virginie Escriou, Nathalie Mignet and Andrew Miller)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eHydrodynamic-Pressure-Based Non-Viral Nucleic Acid Delivery \u003ci\u003e(Takeshi Suda, Kenya Kamimura, Guisheng Zhang and Dexi Liu)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eElectrotransfer\/Electroporation for Non-Viral Nucleic Acid Delivery \u003ci\u003e(Pascal Bigey, Richard Heller and Daniel Scherman)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eImaging of Gene Delivery \u003ci\u003e(Georges Vassaux, Peggy Richard-Fiardo, Béatrice Cambien and Philippe Franken)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003e\u003ci\u003eTherapeutic Applications:\u003c\/i\u003e\u003c\/b\u003e\u003cul\u003e\n\u003cli\u003eOncolytic Adenoviruses for Cancer Gene Therapy \u003ci\u003e(Gunnel Hallden, Yaohe Wang, Han-Hsi Wong and Nick R Lemoine)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eProgress in DNA Vaccine Approaches for Cancer Immunotherapy \u003ci\u003e(Geoffrey D Hannigan and David B Weiner)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eGene Therapy of the Beta-Hemoglobinopathies \u003ci\u003e(Emmanuel Payen, Charlotte Colomb, Olivier Negre, Marina Cavazzana-Calvo, Salima Hacein-Bey-Abina, Yves Beuzard and Philippe Leboulch)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eGene Therapy for Hemophilia A and B \u003ci\u003e(Nisha Nair, Marinee Chuah and Thierry VandenDriessche)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eExperimental and Clinical Ocular Gene Therapy \u003ci\u003e(Alexis-Pierre Bemelmans and José-Alain Sahel)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eGene Therapy of Neurological Diseases \u003ci\u003e(Lisa M Stanek, Lamya S Shihabuddin and Seng H Cheng)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eGenetic Therapy of Muscle Diseases: Duchenne Muscular Dystrophy \u003ci\u003e(Takis Athanasopoulos, Susan Jarmin, Helen Foster, Keith Foster, Jagjeet Kang, Taeyoung Koo, Alberto Malerba, Linda Popplewell, Daniel Scherman and George Dickson)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eInduced Pluripotent Stem Cells and Gene Targeting for Regenerative Medicine \u003ci\u003e(Jizhong Zou and Linzhao Cheng)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003e\u003ci\u003eGene Vector Production:\u003c\/i\u003e\u003c\/b\u003e\u003cul\u003e\n\u003cli\u003eProduction and Purification of Viral Vectors and Safety Considerations Related to Their Use \u003ci\u003e(Otto-Wilhelm Merten, Matthias Schweizer, Parminder Chahal and Amine Kamen)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eProduction and Purification of Plasmid Vectors \u003ci\u003e(Martin Schleef)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\u003cbr\u003e\u003cb\u003eReadership:\u003c\/b\u003e Master, PhD or MD students, post-doctoral scientists or medical doctors, and any scientists using gene transfer techniques or implementing gene therapy strategies.\u003cbr\u003e","brand":"Imperial College Press","offers":[{"title":"Default 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