{"product_id":"9781908979650","title":"ALZHEIMER'S DISEASE: Molecular Basis of Amyloid-Beta Protein Aggregation and Fibril Formation","description":"\u003cp\u003e Alzheimer's disease is the most common form of senile dementia, affecting more than 24 million people worldwide. It is characterised pathologically by abnormally high levels of neurofibrillary tangles resulting from the accumulation of tau protein in dead and dying neurons, and by elevated numbers of senile plaques in the cortex and hippocampus of the brain. The major component of senile plaques is a small protein of 39–43 amino acids called amyloid-β (Aβ). Thus far, no treatment has been shown to slow the progression of sporadic and familial Alzheimer's disease.\u003c\/p\u003e\u003cp\u003eA large body of evidence points, however, to the early Aβ-formed oligomers as the primary toxic species in Alzheimer's disease. A powerful strategy for developing pharmaceutical treatments against Alzheimer's is to elucidate the pathways of oligomer formation and determine the structures of the toxic aggregates.\u003c\/p\u003e\u003cp\u003eThis book provides a panoramic view across recent \u003ci\u003ein vitro\u003c\/i\u003e and \u003ci\u003ein vivo\u003c\/i\u003e studies along with state-of-the-art computer simulations, designed to increase the readers' understanding of Aβ oligomerisation and fibril formation. At the same time, the book delves into the pathogenesis of familial and sporadic Alzheimer's disease at the atomic level of detail.\u003c\/p\u003e\u003cp\u003eWritten by leading authors in their respective fields, this book will be valuable to all scientists working on Alzheimer's disease.\u003c\/p\u003e\u003cb\u003eContents:\u003c\/b\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cb\u003e\u003ci\u003eCellular and In Vitro Aspects of Amyloid-Beta (Aβ) Aggregation:\u003c\/i\u003e\u003c\/b\u003e\u003cul\u003e\n\u003cli\u003eAmyloid Hypothesis: Molecular and Cellular Aspects of Toxicity \u003ci\u003e(Rakez Kayed and Cristian A Lasagna-Reeves)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eModels of Wild-Type and Disease-Causing Mutant β-Amyloid Fibrils. Insights from Solid-State Nuclear Magnetic Resonance Spectroscopy \u003ci\u003e(Stephen C Meredith)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eBiophysical Characterization of Aβ Assembly \u003ci\u003e(Eric Y Hayden and David B Teplow)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eCoordination of Metal Ions to β-Amyloid Peptide: Impact on Alzheimer's Disease \u003ci\u003e(Peter Faller, Giovanni La Penna, Christelle Hureau and Sara Furlan)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eAmyloidogenesis, Neurogenesis, Learning, and Memory in Alzheimer's Disease: Lessons from Transgenic Mouse Models \u003ci\u003e(Laure Verret and Claire Rampon)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eInhibitor Design Against Cytotoxic β-Amyloid Species \u003ci\u003e(Andrew J Doig)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003e\u003ci\u003eBioinformatics and Computer Simulations of Aβ Aggregation Under Various Environmental Conditions:\u003c\/i\u003e\u003c\/b\u003e\u003cul\u003e\n\u003cli\u003eKinetics of Amyloid Growth \u003ci\u003e(Jessica Nasica-Labouze and Normand Mousseau)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eProbing the Stability of Fibril and Tubular Species Using All-Atom Molecular Dynamics Simulations in Solution: Insight into Polymorphism \u003ci\u003e(Yifat Miller, Buyong Ma and Ruth Nussinov)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eMechanisms of Growth of β-Amyloid Fibrils and Binding of Non-Steroidal Anti-Inflammatory Drug Ligands \u003ci\u003e(Takako Takeda and Dmitri Klimov)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eExploring the Structures of β-Amyloid Oligomers in Aqueous Solution Using Coarse-Grained Protein Models \u003ci\u003e(Yassmine Chebaro and Philippe Derreumaux)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003ePathways of Amyloid Fibril Formation Using a Simplified Peptide Model \u003ci\u003e(Riccardo Pellarin)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eFrom Disordered Amyloid β-Proteins to Soluble Oligomers and Protofibrils Using Discrete Molecular Dynamics \u003ci\u003e(Mark Betnel, Nikolay V Dokholyan and Brigita Urbanc)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eAβ Proteins–Lipid Membrane Interaction: Computational Simulation Study \u003ci\u003e(Yuguang Mu)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eMolecular Insights into the Assembly of β-Amyloid on Surfaces and Carbon Nanotubes \u003ci\u003e(Guanghong Wei, Yin Luo and Zhaoming Fu)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eInhibiting Peptide and Protein Self-Aggregation: What Can Simulations Tell Us? \u003ci\u003e(Joan-Emma Shea and Giorgio Colombo)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\u003cbr\u003e\u003cb\u003eReadership:\u003c\/b\u003e General public, PhD students, postdocs, as well as all scientists working in the following fields: Alzheimer's disease, amyloids, neuroscience, oligomers, protofibrils, fibrils, toxicity, structures, dynamics, kinetics, thermodynamics, all-atom and coarse grained simulations, biophysics, memory, learning, transgenic mouse models, metal ions, membrane, nanoparticles, computational chemistry, drug design and bioinformatics.\u003cbr\u003e","brand":"Imperial College Press","offers":[{"title":"Default Title","offer_id":47151372370160,"sku":"9781908979650","price":66.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0737\/7593\/9824\/files\/9781908979650_p0.jpg?v=1763623739","url":"https:\/\/shop-qa.barnesandnoble.com\/products\/9781908979650","provider":"Barnes \u0026 Noble (DEV)","version":"1.0","type":"link"}