{"product_id":"9783038421351","title":"Biofilm-Based Nosocomial Infections","description":"\u003cp\u003eThe well-known persistence in the nosocomial environment of multidrug resistant bacterial\u003c\/p\u003e\u003cp\u003eand fungal species, today responsible for a wide variety of healthcare-associated infections, is\u003c\/p\u003e\u003cp\u003ebelieved to be greatly promoted by the ability of most of them to adhere and to grow in sessile\u003c\/p\u003e\u003cp\u003emode on mucosal and soft tissues of hospitalized patients, as well as on the inner and outer\u003c\/p\u003e\u003cp\u003esurfaces of indwelling medical devices, including intravenous catheters, orthopaedic, cardiac\u003c\/p\u003e\u003cp\u003evalves, intrauterine devices, and contact lenses.\u003c\/p\u003e\u003cp\u003eIn this regard, a large number of these microorganisms, such as Acinetobacter baumannii,\u003c\/p\u003e\u003cp\u003eCandida albicans, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and\u003c\/p\u003e\u003cp\u003eStaphylococcus aureus, give rise to highly organized, sessile community defined biofilms, in\u003c\/p\u003e\u003cp\u003ewhich microbes grow encased in a hydrated matrix of extracellular polymeric substances\u003c\/p\u003e\u003cp\u003eproduced by themselves and are well protected from the attack of antimicrobial molecules and\u003c\/p\u003e\u003cp\u003efrom the host immune response, by resisting phagocytosis and other body's defense systems.\u003c\/p\u003e\u003cp\u003eThe great influence of the sessile growth on the effectiveness of the antibiotic therapies is due\u003c\/p\u003e\u003cp\u003eto both the structure and function of these microbial communities, making these also 1000\u003c\/p\u003e\u003cp\u003etimes more tolerant to antibiotics and disinfectants. Thus, alternative approaches to the\u003c\/p\u003e\u003cp\u003ecommon antibiotic treatments are emerging for preventing and treating both the mono-species\u003c\/p\u003e\u003cp\u003eand the most frequent multi-species biofilms, including enzymes able to disrupt mature\u003c\/p\u003e\u003cp\u003ebiofilms and new biomaterials for the coating of medical devices to counteract microbial\u003c\/p\u003e\u003cp\u003eadhesion and biofilm formation.\u003c\/p\u003e\u003cp\u003eThe aim of this Special Issue is to report on the state-of-art of the basic and applied research\u003c\/p\u003e\u003cp\u003ein the field of biofilm-based nosocomial infections that can be acquired by patients in both\u003c\/p\u003e\u003cp\u003egeneral hospitals and long-term care settings. Particularly, the involvement of microbial\u003c\/p\u003e\u003cp\u003ebiofilms in medical device-related infections and other healthcare-associated infections, so far\u003c\/p\u003e\u003cp\u003eunderestimated and\/or scarcely investigated, has been considered, reviewed, and discussed.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e","brand":"MDPI AG","offers":[{"title":"Default Title","offer_id":47034934329584,"sku":"9783038421351","price":41.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0737\/7593\/9824\/files\/9783038421351_p0.jpg?v=1763711831","url":"https:\/\/shop-qa.barnesandnoble.com\/products\/9783038421351","provider":"Barnes \u0026 Noble (DEV)","version":"1.0","type":"link"}