{"product_id":"9783832542771","title":"Mathematical Modelling of the Canonical NF- kappaB Pathway","description":"\u003cp\u003eThe regulation of the transcription factor NF-kappaB plays a central role in physiological processes by influencing cell differentiation, proliferation and survival. Experiments revealed great differences in the dynamical behaviour of NF-kappaB ranging from sustained oscillations to damped oscillations and monotone increase evolving to a stable steady state. In this work, a theoretical approach was used to determine internal sources of the observed variability in the dynamics. A core model of the canonical NF-kappaB pathway was developed to study the dynamical properties using a bifurcation analysis. The total NF-kappaB concentration as well as the transcription rate constant of the NF-kappaB inhibitor IkappaBalphawere identified as two key parameters that influence the dynamics of NF-kappaB. Further, the activation and deactivation of NF-kappaB is tightly regulated by negative feed-back loops. The transcription of the two NF-kappaB inhibitors IkappaBalphaand A20 is induced by NF-kappaB itself. In this work, a mathematical model was developed comprising both negative feedbacks to determine if post-transcriptional regulation of the two inhibitor mRNAs by the RNA-binding protein RC3H1 can impact the NF-kappaB signal transduction. Additionally, the interplay of the two feedbacks was analysed and cell type specific differences were examined. Again, the total NF-kappaB concentration was found to have a crucial impact. It determines the influence of RC3H1 on the NF-kappaB activity and the interplay of the two feedbacks.\u003c\/p\u003e","brand":"Logos Verlag Berlin","offers":[{"title":"Default Title","offer_id":47053191086320,"sku":"9783832542771","price":67.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0737\/7593\/9824\/files\/9783832542771_p0.jpg?v=1763687557","url":"https:\/\/shop-qa.barnesandnoble.com\/products\/9783832542771","provider":"Barnes \u0026 Noble (DEV)","version":"1.0","type":"link"}