{"product_id":"9783836460804","title":"Polymeric Micelle Nanocarriers For The Treatment Of Disseminated Candidiasis","description":"The potential of polymeric micelles formed from biocompatible or generally regarded as safe (GRAS) materials as sustained release nanocarriers for amphotericin B has been evaluated in this dissertation as further development can proceed without an explicit concern for biocompatibility which may slow progress of particulate carriers prepared from novel synthetic polymers. PEG-phospholipid (PEG-DSPE) micelles clearly prevented AmB induced toxicity pointing to stable drug incorporation, in vitro. However, drug release and absorption kinetics revealed that AmB was rapidly dissociated from PEG-DSPE micelles in serum albumin, a likely situation in vivo. Cholesterol co-incorporation influenced properties of PEG-DSPE micelles and slowed AmB release in serum albumin raising promise as long circulating carriers for AmB delivery. Further, AmB in PEG-DSPE micelles was stable in saline when combined with 5-fluorocytosine and solubilized rapamycin. Hence, PEG-DSPE micelles represent an interesting alternative to deoxycholate-AmB, particularly in combination therapy involving AmB with optional continuous infusion or sodium supplementation.","brand":"VDM Verlag Dr. Mueller Aktiengesellschaft \u0026 Co. KG","offers":[{"title":"Default Title","offer_id":47052246581488,"sku":"9783836460804","price":89.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0737\/7593\/9824\/files\/9783836460804_p0.jpg?v=1763688353","url":"https:\/\/shop-qa.barnesandnoble.com\/products\/9783836460804","provider":"Barnes \u0026 Noble (DEV)","version":"1.0","type":"link"}