{"product_id":"9783836467452","title":"Biomimetic Modeling of Superoxide Reductase - Synthetic Insight Into a Natural Process","description":"SOR is a non-heme thiolate-ligated metalloenzyme, consisting of a ferrous center ligated by four histidines and a cysteinate residue. It is responsible for superoxide detoxification in anaerobic and microaerophilic organisms by reducing superoxide to hydrogen peroxide. A novel biomimetic model of the active site of SOR, [Fe(II)cyclam-PrS]+ is described. This complex reacts with superoxide under protic conditions at cryogenic temperatures to form the intermediate [Fe(III)cyclam-PrS(OOH)]+. This is a rare example of a high-spin Fe(III)-OOH species, and is the first reported example of a high-spin non-heme Fe(III)-OOH containing a trans thiolate. Using a synthetic approach to achieve biomimicry, new insight into the natural role of thiolates in metalloenzymes is described.","brand":"VDM Verlag Dr. Mueller E.K.","offers":[{"title":"Default Title","offer_id":47063152132336,"sku":"9783836467452","price":76.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0737\/7593\/9824\/files\/9783836467452_p0.jpg?v=1763687809","url":"https:\/\/shop-qa.barnesandnoble.com\/products\/9783836467452","provider":"Barnes \u0026 Noble (DEV)","version":"1.0","type":"link"}