{"product_id":"9789814440684","title":"Autophagy Of The Nervous System: Cellular Self-digestion In Neurons And Neurological Diseases: Cellular Self-Digestion in Neurons and Neurological Diseases","description":"\u003cp\u003eWhat is autophagy? Why would neurons digest parts of themselves through autophagy? How can autophagy save the lives of cells under some conditions, but act as an accomplice to cell death in others? By what mechanisms are autophagy-related processes dysregulated in neurological diseases, and are there therapeutic strategies to correct or compensate for their dysfunction? This book provides an expert view of major concepts in autophagy research with a focus on autophagy in neurons. Experimental evidence for evolutionarily conserved and specialized regulatory mechanisms for autophagy in the mammalian nervous system will be presented, including recent data on braking mechanisms. Areas of intersection with cell death, the ubiquitin-proteasome system, chaperone-mediated autophagy, and the endocytic pathway will be reviewed, along with emerging areas of mitochondrial autophagy (mitophagy) and the autophagic regulation of neuritic\/synaptic processes. Advances in delineating mechanisms by which autophagy is involved in the pathophysiology of neurological disorders, including Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis, ischemia\/hypoxia and lysosomal storage diseases, will be discussed along with current drug development strategies targeting autophagy.\u003c\/p\u003e\u003cb\u003eContents:\u003c\/b\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cb\u003e\u003ci\u003eNeuronal Autophagy: Cellular Process and Regulation:\u003c\/i\u003e\u003c\/b\u003e\u003cul\u003e\n\u003cli\u003eThe Cellular Process of Autophagy and Control of Autophagy in Neurons \u003ci\u003e(Nicole C McKnight, Noboru Mizushima and Zhenyu Yue)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eAutophagosome Maturation, Endocytosis and Neurodegenerative Disease \u003ci\u003e(Ai Yamamoto and Anne Simonsen)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eCross-Talk Between the Ubiquitin-Proteasome System and Macroautophagy \u003ci\u003e(Serhiy Pankiv and Terje Johansen)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eChaperone-Mediated Autophagy (CMA) in Neurons \u003ci\u003e(Maria Xilouri, Hsiao-Yu Peng and Leonidas Stefanis)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eMaintaining Autophagic Balance: A Role for Brakes \u003ci\u003e(Salvatore J Cherra, III and Charleen T Chu)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003e\u003ci\u003eAutophagy and Neurological Diseases:\u003c\/i\u003e\u003c\/b\u003e\u003cul\u003e\n\u003cli\u003eAutophagy and Its Cross-Talk with Cell Death in Neural Development \u003ci\u003e(Sabrina Di Bartolomeo and Francesco Cecconi)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eAutophagy in the Retina: Development, Physiology and Pathology \u003ci\u003e(Patricia Boya)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eGenetic Mouse Models for Elucidation of Autophagy-Lysosomal Systems in Neurons Under Physiologic and Pathologic Conditions \u003ci\u003e(Masaaki Komatsu, Masato Koike, Yoshinobu Ichimura and Yasuo Uchiyama)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eAutophagy in Amyotrophic Lateral Sclerosis \u003ci\u003e(Jozsef Gal and Haining Zhu)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eAutophagy Failure in Alzheimer's Disease and Lysosomal Storage Disorders: A Common Pathway to Neurodegeneration? \u003ci\u003e(Devin M Wolfe and Ralph Nixon)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eAutophagy in Huntington's and Parkinson's Diseases: Pathogenic Mechanism and Therapeutic Potentials \u003ci\u003e(Junghyun Lim, Lauren G Friedman, Nicole C McKnight and Zhenyu Yue)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eMetabolism, Autophagy and Neurodegeneration \u003ci\u003e(W Haung Yu and Karen E Duff)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eThe Potential of Autophagy Regulation in the Treatment of Neurodegenerative Diseases \u003ci\u003e(Ashley R Winslow, Zeyn W Green-Thompson and David C Rubinsztein)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eLysosome Storage Disorders on the Brain: The Autophagy-Lysosome Pathway Contributes to Disease Pathophysiology and May be Utilized for Therapeutic Benefit \u003ci\u003e(John J Shacka)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003e\u003ci\u003eSpecialized Autophagy: The New Frontier:\u003c\/i\u003e\u003c\/b\u003e\u003cul\u003e\n\u003cli\u003eAutophagy — Roles in Synaptic Structure and Function \u003ci\u003e(Daniela Hernandez and David Sulzer)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eNeuronal Mitochondrial Transport and Turnover via Mitophagy \u003ci\u003e(Zu-Hang Sheng and Charleen T Chu)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eRole of Autophagy in Neurite Degeneration \u003ci\u003eIn Vitro\u003c\/i\u003e \u003ci\u003e(Yi Yang, Xiaoxiang Zheng and Tatsuro Koike)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\u003cbr\u003e\u003cb\u003eReadership:\u003c\/b\u003e Neurologists (clinical), molecular biologists (scientists), and college students.\u003cbr\u003e","brand":"World Scientific Publishing Company, Incorporated","offers":[{"title":"Default Title","offer_id":47143739031792,"sku":"9789814440684","price":58.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0737\/7593\/9824\/files\/9789814440684_p0.jpg?v=1763691054","url":"https:\/\/shop-qa.barnesandnoble.com\/products\/9789814440684","provider":"Barnes \u0026 Noble (DEV)","version":"1.0","type":"link"}