{"product_id":"9789814603843","title":"New Chemistry and New Opportunities from the Expanding Protein Universe: Proceedings of the 23rd International Solvay Conference on Chemistry","description":"\u003cp\u003eA select group of 40 eminent scientists from all parts of the world met to consider the current state of chemical and biological knowledge on the ever-expanding protein universe, and to discuss emerging opportunities for the foreseeable future. Scientific approaches to discover, characterize, and regulate protein functions were discussed over a range of disciplines, including natural product chemistry, microbiology, enzymology, biochemistry, structural biology, chemical biology, and glycobiology. Some notable highlights included discovery of new enzymatic pathways, innovative carbohydrate chemistry, design of proteins containing unnatural amino acids, structural elucidation of complex supramolecular machines, and design and application of small molecule drugs, biologics and biosimilars.\u003c\/p\u003e\u003cp\u003eThis fascinating compendium of scientific presentations and in-depth discussions affords a unique perspective on today's protein chemistry and biology as well as on the challenges for tomorrow.\u003c\/p\u003eNovember 14, 2014 \u003cb\u003eContents:\u003c\/b\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cb\u003e\u003ci\u003eNew Chemistry in the Expanding Protein Universe:\u003c\/i\u003e\u003c\/b\u003e\u003cul\u003e\n\u003cli\u003eNovel Chemistry Still to be Found in Nature \u003ci\u003e(C T Walsh)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eNatural Product Biosynthesis in the Genomic Age \u003ci\u003e(W A van der Donk)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003ePeptide Dendrimers and Polycyclic Peptides \u003ci\u003e(J-L Reymond)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eWhat can Comparative Genomics Reveal about the Mechanisms of Protein Function Evolution? \u003ci\u003e(N L Dawson, R Studer, N Furnham, D Lees, S Das, J Thornton and C Orengo)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eExploring Chromatin Biology Using Protein Chemistry \u003ci\u003e(T W Muir)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eOur Expanding Protein Universe \u003ci\u003e(A Godzik)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eThe Scientific Impact of Freely Available Chemical Probes \u003ci\u003e(A M Edwards)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eDiscussions of Session 1\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003e\u003ci\u003eExploring Enzyme Families and Enzyme Catalysis:\u003c\/i\u003e\u003c\/b\u003e\u003cul\u003e\n\u003cli\u003eMechanistic Enzymology and Catalyst Design \u003ci\u003e(D Hilvert)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eLooking in New Directions for the Origins of Enzymatic Rate Accelerations \u003ci\u003e(J P Klinman)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eComputational Enzyme Design and Methods to Predict the Role of Remote Mutations \u003ci\u003e(K N Houk)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eDiscovering Novel Enzymes, Metabolites and Pathways \u003ci\u003e(J A Gerlt)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eProgramming New Chemistry into the Genetic Code of Cells and Animals \u003ci\u003e(J W Chin)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eExpanding the Enzyme Universe through a Marriage of Chemistry and Evolution \u003ci\u003e(F H Arnold)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eControlled Radical Reactions in Biology and the Importance of Metallo-Cofactor Biosynthesis \u003ci\u003e(J Stubbe)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eDiscussions of Session 2\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003e\u003ci\u003eMicrobiomes and Carbohydrate Chemistry:\u003c\/i\u003e\u003c\/b\u003e\u003cul\u003e\n\u003cli\u003eStructural Basis for Host\/Commensal-Microbe Interactions in the Human Distal Gut Microbiome \u003ci\u003e(I A Wilson)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eCarbohydrate Chemistry and Biology \u003ci\u003e(C-H Wong)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eChemical Biological Proteomics of Bacterial Protein Functionalities in the Human Distal Gut Microbiome \u003ci\u003e(D W Wolan)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eAutomated Oligosaccharide Synthesis: From Insights into Fundamental Glycobiology to Vaccines and Diagnostics \u003ci\u003e(P H Seeberger)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eCarbohydrate-Active Enzymes in Microbiomes \u003ci\u003e(B Henrissat)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eThe Microbiome(s): Microbiota, Families, Functions \u003ci\u003e(A Godzik)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eN-Linked Protein Glycosylation \u003ci\u003e(M Aebi)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eDiscussions of Session 3\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003e\u003ci\u003eGPCRs and Transporters: Ligands, Cofactors, Drug Development:\u003c\/i\u003e\u003c\/b\u003e\u003cul\u003e\n\u003cli\u003eGPCRs and Transporters: Ligands, Cofactors, Drug Development \u003ci\u003e(G von Heijne)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eStudies of GPCR Conformations in Non-Crystalline Milieus \u003ci\u003e(K Wüthrich)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eThe Seven Transmembrane Superfamily \u003ci\u003e(R C Stevens)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eNanobodies for the Structural and Functional Investigation of GPCR Transmembrane Signaling \u003ci\u003e(E Pardon and J Steyaert)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eThe Hidden Pharmacology of the Human GPCR-ome \u003ci\u003e(B L Roth)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eStructures and Reaction Mechanisms of ABC Transporters \u003ci\u003e(K Locher)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eDiscussions of Session 4\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003e\u003ci\u003eBiologicals and Biosimilars:\u003c\/i\u003e\u003c\/b\u003e\u003cul\u003e\n\u003cli\u003eBiologicals and Biosimilars \u003ci\u003e(S Ghose and M G Grütter)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003ePlatform Technologies for the Artificial Pseudo-Natural Product Discovery \u003ci\u003e(H Suga)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eAnticalins\u003csup\u003e®\u003c\/sup\u003e\u0026amp;Pasylation\u003csup\u003e®\u003c\/sup\u003e: New Concepts for Biopharmaceutical Drug Development from Protein Design \u003ci\u003e(A Skerra)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eFrom Natural Antibodies to Synthetic Proteins \u003ci\u003e(S S Sidhu)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eFrom Intact Antibodies to Armed Antibodies \u003ci\u003e(D Neri)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eRegulating Cellular Life Death and Development Using Intracellular Combinatorial Antibody Libraries \u003ci\u003e(R Lerner, J Xie, H Zhang, K Yea, J Blanchard and K Baldwin)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eNanobodies: A Universe of Variable Domains and a Toolbox for Many Trades \u003ci\u003e(L Wyns)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eDiscussions of Session 5\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003e\u003ci\u003eProteins in Supramolecular Machines:\u003c\/i\u003e\u003c\/b\u003e\u003cul\u003e\n\u003cli\u003eAssembly of Filamentous Type 1 Pili from Uropathogenic \u003ci\u003eEscherichia Coli\u003c\/i\u003e Strains \u003ci\u003e(R Glockshuber)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eHIV Envelope and Influenza Hemagglutinin Fusion Glycoproteins and the Quest for a Universal Vaccine \u003ci\u003e(I A Wilson)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eDeconstruction of Iterative Polyketide Synthases \u003ci\u003e(C A Townsend)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eRegulating Ribosome Pausing During Translation \u003ci\u003e(M V Rodnina)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eThe Molecular Mechanics of the Ribosome \u003ci\u003e(J Zhou, L Lancaster, Z Guo, J P Donohue and H F Noller)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eExploring the Dynamics of Supramolecular Machines with Cryo-Electron Microscopy \u003ci\u003e(J Frank)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eCrystallographic Studies of Eukaryotic Ribosomes and Functional Insights \u003ci\u003e(N Ban)\u003c\/i\u003e\n\u003c\/li\u003e\n\u003cli\u003eDiscussions of Session 6\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\u003cbr\u003e\u003cb\u003eReadership:\u003c\/b\u003e Graduates and researchers in protein structure, structural biology and genomics.\u003cbr\u003e\u003cb\u003eKey Features:\u003c\/b\u003e\u003cul\u003e\u003cli\u003eUnique approach to the topic, an outstanding group of contributors, extensive  inclusion of otherwise unpublished material\u003c\/li\u003e\u003c\/ul\u003e","brand":"World Scientific Publishing Company, Incorporated","offers":[{"title":"Default Title","offer_id":47185299177712,"sku":"9789814603843","price":38.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0737\/7593\/9824\/files\/9789814603843_p0.jpg?v=1763691089","url":"https:\/\/shop-qa.barnesandnoble.com\/products\/9789814603843","provider":"Barnes \u0026 Noble (DEV)","version":"1.0","type":"link"}