{"product_id":"9789814632164","title":"Affinity And Efficacy: The Components Of Drug-receptor Interactions: The Components of Drug-Receptor Interactions","description":"\u003cp\u003eThe interaction of a drug with a receptor generates a code of information having components of affinity and efficacy. How this information is translated into a response depends on the unique cells, tissue, organ or system in which the receptor resides. This book describes how to analyze various responses to estimate the affinity and efficacy components of the initial drug–receptor interaction. More specifically, it describes how to measure the affinity and efficacy of drugs through the analysis of single receptor activity, the activation state of a population of receptors, and responses downstream from receptor activation. More light is thrown on ligand-gated ion channels and G protein-coupled receptors in this book.\u003c\/p\u003e\u003cp\u003eThe topics discussed include radioligand binding, estimation of agonist affinity and efficacy, competitive antagonism, inverse agonism, allosteric agonists and modulators, agonist bias, modulation of pathway selectivity, and the estimation of ligand affinity for active and inactive receptor states. The natural history and structure of ligand-gated ion channels, G proteins, and G protein-coupled receptors are also discussed.\u003c\/p\u003e\u003cb\u003eContents:\u003c\/b\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cb\u003e\u003ci\u003eLigand-Gated Ion Channels:\u003c\/i\u003e\u003c\/b\u003e\u003cul\u003e\n\u003cli\u003eLigand-Gated Ion Channels\u003c\/li\u003e\n\u003cli\u003eAffinity and Efficacy of Orthosteric Ligands at Ligand-Gated Ion Channels\u003c\/li\u003e\n\u003cli\u003eCompetitive Interactions Between Orthostheric Ligands at Ligand-Gated Ion Channels\u003c\/li\u003e\n\u003cli\u003eAnalysis of Allosteric Interactions at Ligand-Gated Ion Channels\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003e\u003ci\u003eG Protein-Coupled Receptors:\u003c\/i\u003e\u003c\/b\u003e\u003cul\u003e\n\u003cli\u003e\n\u003ci\u003eG\u003c\/i\u003e Protein-Coupled Receptors and \u003ci\u003eG\u003c\/i\u003e Protein and Arrestin Signaling\u003c\/li\u003e\n\u003cli\u003eAffinity and Efficacy of the Agonist-Receptor-\u003ci\u003eG\u003c\/i\u003e-Protein Interaction\u003c\/li\u003e\n\u003cli\u003eEstimating Affinity and Efficacy by Reverse-Engineering the Response-Clamp Analysis\u003c\/li\u003e\n\u003cli\u003eAnalysis of Agonism and Inverse Agonism in Signaling Pathways that Exhibit Constitutive Activity\u003c\/li\u003e\n\u003cli\u003eAnalysis of Ligand Bias in Receptor Signaling through Different \u003ci\u003eG\u003c\/i\u003e Protein Pathways\u003c\/li\u003e\n\u003cli\u003eCompetitive Interactions Between Orthosteric Ligands in Functional Assays on \u003ci\u003eG\u003c\/i\u003e Protein-Coupled Receptors\u003c\/li\u003e\n\u003cli\u003eAnalysis of Allosterism in Functional Assays on \u003ci\u003eG\u003c\/i\u003e Protein-coupled Receptors\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003e\u003ci\u003eRadioligand Binding:\u003c\/i\u003e\u003c\/b\u003e\u003cul\u003e\u003cli\u003eAnalysis of Drug-receptor Interactions Using Radioligand Binding Assays on \u003ci\u003eG\u003c\/i\u003e Protein-coupled Receptors\u003c\/li\u003e\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\u003cbr\u003e\u003cb\u003eReadership:\u003c\/b\u003e Postgraduates and researchers in pharmacology and physiology, professionals in the pharmaceutical industry, neuroscience researchers.\u003cbr\u003e\u003cb\u003eKey Features:\u003c\/b\u003e\u003cul\u003e\u003cli\u003eIt presents laymen and mathematicians alike with beautiful pieces of mathematics, and studies techniques of both poetry and mathematics that contribute to beauty\u003c\/li\u003e\u003c\/ul\u003e","brand":"World Scientific Publishing Company, Incorporated","offers":[{"title":"Default Title","offer_id":47185356718320,"sku":"9789814632164","price":68.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0737\/7593\/9824\/files\/9789814632164_p0.jpg?v=1763691319","url":"https:\/\/shop-qa.barnesandnoble.com\/products\/9789814632164","provider":"Barnes \u0026 Noble (DEV)","version":"1.0","type":"link"}