Pirut Live (Ltd) (Rmst)

Aimed at "drug discoverers" - i.e. any scientist who is interested in neurodegenerative diseases in general, and in finding disease-modifying treatments in particular - the first edition of Neurodegenerative Diseases: Molecular Targets and Disease-Modifying Compounds will contain both a detailed, discipline-specific coverage (paragraphs on medicinal chemistry, on clinical and preclinical characterization of compounds in development, on target identification and validation, on genetic factors influencing a pathology, etc.) and a drug discovery-oriented, overall evaluation of each target (validation, druggability, existing leads, etc.). Together these will satisfy the needs of various audiences, including in vitro biologists, pharmacologists, medicinal chemists, etc.

•Written to provide a comprehensive coverage of disease-modifying mechanisms and compounds against neurodegenerative diseases
•Provides a “drug discovery” application oriented perspective, evaluating targets and candidates for their overall therapeutic potential
•Provides discipline-specific chapters (medicinal chemistry, target validation, preclinical and clinical development
•Provides an overview on a number of molecular mechanisms (e.g. phosphorylation, chaperon refolding, ubiquitination, autophagy, microtubule transportation, protease cleavage, etc.) with relevance for any disease area
•Contains a more thorough description of the therapeutic relevance of ~10 specific molecular targets