Vitaphone Cavalcade of Musical Comedy Shorts [6 Discs]

This work was aimed at studying the effects of recombinant BMP on the consolidation phase in a long bone distraction osteogenesis model. Callus mineralization was monitored using radiographic, sonographic, densitometric and histologic analysis. Rh-BMP-7 (dose of 30μg/kg) was not able to accelerate mineralization of the regenerate as cysts developped within the calluses. Rh-BMP-2 (doses of 100 and 250μg/kg) was efficient in stimulating bone mineralization of the regenerate. A dose effect was also identified on radiographic and densitometric parametres with the rh-BMP-2. Collagenic sponge carrier was identified as well adapted to clinical use in a distraction osteogenesis procedure. This experimental work is a first step to the use of recombinant BMP in clinical practice in the field of leg length discrepancy and bone loss surgical management. BMPs may help accelerating the consolidation phase thus reducing the morbidity associated with distraction osteogenesis procedures.