Eureka, California

Eureka (Hupa: do'-wi-lotl-ding' Karuk: uuth) is the principal city and county seat of Humboldt County in the Redwood Empire region of California. The city is located on U.S. Route 101 on the shores of Humboldt Bay, 270 miles (430 km) north of San Francisco and 100 miles (160 km) south of the Oregon border. At the 2010 census, the population of the city was 27,191, and the population of Greater Eureka was 45,034. Eureka is the largest coastal city between San Francisco and Portland, and the westernmost city of more than 25,000 residents in the 48 contiguous states.