Cancer Drug Design and Discovery

The ultimate authoritative source of information on the design of new anticancer agents, written by some of the leaders in the field, Cancer Drug Design and Discovery covers a number of recent notable successes as well as discussions of especially promising new therapies. These advances have provided information on targets involved in specific cancers that will hopefully lead to effective medicines for at least some of the common solid tumors. Unique sections explain the basic underlying principles of cancer drug development and provide a practical introduction to modern methods of cancer drug design.

More than simply a collection of chapters describing cancer drug chemistry and biology, this book also provides authoritative clinical perspectives on clinical trials and how they may be best structured to exploit molecular targeting and minimize failure. The biological and chemical reasons behind why drugs fail are extensively explored, and strategies for overcoming them and optimizing drug properties are discussed. Issues such as resistance and angiogenesis are emphasized, and there is overall a focus on small molecule approaches. Includes drugs under development in addition to those drugs currently available. Provides authoritative clinical perspective on trials of new anticancer agents. Presents drug discovery examples through the use of case histories in areas such as DNA repair, cell cycle inhibitors, HSP90 inhibition and kinase targets.