Basic Aspects of Catechol-O-Methyltransferase and the Clinical Applications of its Inhibitors

Volume 95 of International Review of Neurobiology focuses on Catechol-O-methyltransferase inhibition, and its clinical application in relation to Parkinson’s disease. Chapters cover COMT gene and proteins, L-dopa treatment in Parkinson’s disease, the latest research on COMT inhibitors and their clinical applications, as well as future prospects for their use.

• Up-to-date summary of biochemistry and pharmacology of COMT and its inhibitors
• Preclinical models in COMT inhibitor devlopment
• Transgenic COMT mice – latest information summarized
• Chemistry of COMT inhibitors and their design with molecular modelling
• COMT gene and its regulation and relation to dopamine related diseases
• Role of cofactor SAM regulation in relation to homocysteine
• Nonclinical and clinical safety of COMT inhibitors summarized
• Future prospects of COMT inhibitors in Parkinson’s disease