DNA Topology

The basic structure of the DNA double helix has been recognized for many years, but more recently the existence and biological importance of different conformations of DNA have become known. The most prominent of these are the "topological" deformations such as supercoiling and catenation. Almost all biological processes involving DNA—such as replication, recombination, and transcription—have effects on, and are affected by, the topological state of the DNA. DNA Topology: In Focus provides clear, concise explanations of these concepts in their biological contexts, making it a valuable text for students of molecular biology, biochemistry and related disciplines, and for all researchers in this field.