Eu Powers Under External Pressure: How the Eu's External Actions Alter Its Internal Structures

Purchase includes free access to book updates online and a free trial membership in the publisher's book club where you can select from more than a million books without charge. Chapters: Frederick Sanger, Arthur Peacocke, Phyllis Starkey, Rodney Robert Porter, William Astbury, Dorothy Maud Wrinch, David Andrew Phoenix, Peter D. Mitchell, Lynne Jones, Frederick Gowland Hopkins, William John Young, Tim Hunt, Juda Hirsch Quastel, Arthur Harden, Robin Hill, Alan Fairlamb, Edward Abraham, Archer John Porter Martin, Jennifer Moyle, Frank George Young, John Ashworth, Ernest Baldwin, Gilbert Smithson Adair, Charles Suckling, Chris Freeman. Excerpt: Trypanothione. The glutathione moieties are shown in black and the polyamine linker in red. Alan Hutchison Fairlamb , CBE , FRSE , FLS (born 30 April 1947, Newcastle upon Tyne , England ) is a Wellcome Trust Principal Research Fellow, Professor of Biochemistry and Head of the Division of Biological Chemistry and Drug Discovery at the University of Dundee , Scotland. He is also a member of the Scientific and Technical Advisory Committee of the Special Programme for Research and Training in Tropical Diseases (TDR) — an independent global programme of scientific collaboration co-sponsored by UNICEF , UNDP , the World Bank and WHO . Professor Alan Fairlamb and his team study the protozoan parasites causing three different diseases - sleeping sickness , Chagas disease and leishmaniasis . He was one of the 250 scientists involved in the genome sequencing of these parasites . In 1985, Alan Fairlamb discovered a unique thiol compound present in these parasites, and named it trypanothione . This thiol metabolite is quite different from its human equivalent, glutathione . Trypanothione allows the parasites to fend off free radicals and other toxic oxidants produced by the immune system of the infected patient, and was shown to be vital for parasite survival and virulence. For instance, antimonials neutralize the Leishmania parasite s...